Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT2 | P34897 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | GBA1 | P04062 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6784589 | 0.80 | SIRT2 (0.51) | KDM4EALDH1A1SMN1; SMN2MEN1MAPT | |
| SCHEMBL5116360 | 0.79 | P2RX7 (0.44) | PIK3CAMCHR1 | |
| SCHEMBL15158327 | 0.78 | AKT1 (0.55) | MEN1KMT2APIK3CDPIK3CACYP3A4 | |
| SCHEMBL6784582 | 0.77 | SIRT2 (0.43) | KDM4EALDH1A1CYP1A2HPGDSMN1; SMN2 | |
| SCHEMBL3381597 | 0.75 | PIK3CD (0.48) | PIK3CDPIK3CACYP3A4PIK3CBAKT1 | |
| SCHEMBL12909207 | 0.73 | KMT2A (0.44) | KDM4EGAAALDH1A1CYP1A2HPGD | |
| SCHEMBL3381645 | 0.72 | AKT1 (0.65) | KDM4EGAAALDH1A1HPGDHSD17B10 | |
| SCHEMBL15221152 | 0.70 | GAA (0.41) | KDM4EGAAALDH1A1CYP1A2HPGD | |
| SCHEMBL5626297 | 0.65 | KMT2A (0.57) | ALDH1A1CYP1A2HSD17B10SMN1; SMN2MAPT | |
| SCHEMBL21997986 | 0.65 | PKM (0.53) | KDM4EGAAALDH1A1CYP1A2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050256157-A1 | Combination therapy with CHK1 inhibitors | CHIRON CORPORATION | 2005-11-17 | — | — | US | disclosed |
| US-20040097545-A1 | Quinolinone derivatives | NOVARTIS AG (CH) | 2004-05-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050256157-A1 | Combination therapy with CHK1 inhibitors | CHEK1, CHEK2, RAD1 | SHMT2 863/4885KDM4E 2750/4885GAA 3154/4885 |
| US-20040097545-A1 | Quinolinone derivatives | SLCO1B1, SLCO1B3, SLCO1A2 | SHMT2 3735/4885KDM4E 4627/4885GAA 204/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.