Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNMA1 | Q12791 | 4/20 | 0.69 |
| ▸ | GAA | P10253 | 9/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | NPC1 | O15118 | 5/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 3/20 | 0.54 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1224549 | 0.86 | KCNMA1 (0.62) | KCNMA1GAASMN1; SMN2MAPTNPC1 | |
| SCHEMBL8006888 | 0.84 | HPGD (0.72) | KCNMA1GAASMN1; SMN2MAPTNPC1 | |
| SCHEMBL27877164 | 0.83 | CXCR2 (0.67) | KCNMA1GAASMN1; SMN2MAPTNPC1 | |
| SCHEMBL11850690 | 0.83 | HPGD (0.70) | KCNMA1GAASMN1; SMN2MAPTNPC1 | |
| SCHEMBL6029542 | 0.82 | KCNMA1 (0.84) | KCNMA1GAASMN1; SMN2MAPTNPC1 | |
| SCHEMBL10873010 | 0.82 | KCNMA1 (1.00) | KCNMA1GAASMN1; SMN2MAPTNPC1 | |
| SCHEMBL14363390 | 0.81 | KCNMA1 (0.66) | KCNMA1GAASMN1; SMN2MAPTNPC1 | |
| SCHEMBL12339789 | 0.81 | KCNMA1 (0.57) | KCNMA1GAASMN1; SMN2MAPTNPC1 | |
| SCHEMBL2605548 | 0.81 | KCNMA1 (0.82) | KCNMA1GAASMN1; SMN2MAPTNPC1 | |
| SCHEMBL14354719 | 0.81 | GAA (0.72) | KCNMA1GAASMN1; SMN2MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8168650-B2 | Therapeutic uses of bicyclic ligands of sigma 2 receptor | WASHINGTON UNIVERSITY (US) | 2012-05-01 | — | — | US | disclosed |
| US-20100048614-A1 | THERAPEUTIC USES OF BICYCLIC LIGANDS OF SIGMA 2 RECEPTOR | WASHINGTON UNIVERSITY (US) | 2010-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048614-A1 | THERAPEUTIC USES OF BICYCLIC LIGANDS OF SIGMA 2 RECEPTOR | SIGMAR1, TMEM97, BAD | KCNMA1 1319/4885GAA 2640/4885SMN1; SMN2 2343/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.