Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24089693 | 0.83 | S1PR4 (0.42) | PRKDCPOLBL3MBTL1LMNAALDH1A1 | |
| SCHEMBL18190177 | 0.78 | ABCB1 (0.43) | L3MBTL1TMEM97ALDH1A1MEN1KMT2A | |
| SCHEMBL1864142 | 0.77 | ATM (0.36) | POLBALDH1A1MAPTKDM4EMEN1 | |
| SCHEMBL4755289 | 0.77 | — | — | |
| SCHEMBL8544940 | 0.77 | — | — | |
| SCHEMBL592513 | 0.75 | — | — | |
| Fluoride SCHEMBL9450647 | 0.73 | — | — | |
| SCHEMBL14561874 | 0.71 | ALDH1A1 (0.48) | LMNATMEM97ALDH1A1MAPTKDM4E | |
| SCHEMBL10818982 | 0.71 | ALDH1A1 (0.32) | POLBLMNAALDH1A1MAPTRECQL | |
| SCHEMBL6397383 | 0.69 | ALOX5 (0.41) | POLBL3MBTL1LMNATMEM97ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6878705-B2 | 4-oxo-4,7-dihydrofuro[2,3-b]pyridine-5-carboxamide antiviral agents | PFIZER (US) | 2005-04-12 | — | — | US | disclosed |