Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 14/20 | 0.52 |
| ▸ | THRB | P10828 | 14/20 | 0.52 |
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5359710 | 0.80 | THRA (0.56) | THRATHRBPPARG | |
| SCHEMBL12312840 | 0.80 | THRB (0.66) | THRATHRBPPARG | |
| SCHEMBL5367331 | 0.80 | THRA (0.82) | THRATHRBPPARG | |
| SCHEMBL5359707 | 0.75 | THRB (0.60) | THRATHRBPPARG | |
| SCHEMBL5358473 | 0.75 | THRB (0.52) | THRATHRBPPARG | |
| SCHEMBL5356542 | 0.73 | THRA (0.54) | THRATHRBPPARG | |
| SCHEMBL5544018 | 0.69 | THRA (1.00) | THRATHRB | |
| SCHEMBL5964537 | 0.68 | THRA (0.62) | THRATHRB | |
| SCHEMBL5355147 | 0.67 | THRA (0.46) | THRATHRBPPARG | |
| SCHEMBL5964844 | 0.67 | THRA (0.58) | THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050107347-A1 | Prime ring substituted thyroid receptor antagonists for the treatment of cardiac and metabolic disorders | KARO BIO AB (SE) | 2005-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107347-A1 | Prime ring substituted thyroid receptor antagonists for the treatment of cardiac and metabolic disorders | TSHR, THRB, THRA | THRA 3/4885THRB 2/4885PPARG 20/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.