⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2035324 | 1.00 | — | — | |
| SCHEMBL194255 | 1.00 | — | — | |
| SCHEMBL10912208 | 0.97 | TP53 (0.42) | — | |
| SCHEMBL9630250 | 0.89 | ALDH1A1 (0.37) | — | |
| Carbonotrithioic Acid SCHEMBL28986971 | 0.87 | ALDH1A1 (0.36) | — | |
| Malic Acid SCHEMBL6120864 | 0.81 | SMN1; SMN2 (0.65) | — | |
| SCHEMBL10380813 | 0.79 | GPR84 (0.50) | — | |
| SCHEMBL42068 | 0.78 | — | — | |
| SCHEMBL106774 | 0.78 | — | — | |
| SCHEMBL12927538 | 0.78 | CPT2 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 236 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119709892-A | Method for preparing (S) -2-hydroxy-3, 3-dimethylbutyric acid by using enzymatic method | 尚科生物医药（上海）有限公司 | 2025-03-28 | — | — | CN | claimed |
| CN-116818930-A | Chiral detection method of (S) - (-) -2-hydroxy-3, 3-dimethylbutyric acid | 上海吉奉生物科技有限公司 | 2023-09-29 | — | — | CN | claimed |
| JP-4679150-B2 | — | — | 2011-04-27 | — | — | JP | claimed |
| EP-1556358-B1 | ENANTIOSELECTIVE ALKYLATION OF TRICYCLIC COMPOUNDS | SCHERING CORP (US) | 2007-06-20 | — | — | EP | claimed |
| US-7049440-B2 | Chemical intermediate for tricyclic compound | SCHERING CORPORATION (US) | 2006-05-23 | — | — | US | claimed |
| EP-1556358-A2 | ENANTIOSELECTIVE ALKYLATION OF TRICYCLIC COMPOUNDS | SCHERING CORPORATION (US) | 2005-07-27 | — | — | EP | claimed |
| US-20040122232-A1 | Enantioselective process | SCHERING CORPORATION | 2004-06-24 | — | — | US | claimed |
| WO-2004031153-A2 | ENANTIOSELECTIVE ALKYLATION OF TRICYCLIC COMPOUNDS | SCHERING CORPORATION (US) | 2004-04-15 | — | — | WO | claimed |
| CN-119709892-A | Method for preparing (S) -2-hydroxy-3, 3-dimethylbutyric acid by using enzymatic method | 尚科生物医药（上海）有限公司 | 2025-03-28 | — | — | CN | disclosed |
| CN-119709892-A | Method for preparing (S) -2-hydroxy-3, 3-dimethylbutyric acid by using enzymatic method | 尚科生物医药（上海）有限公司 | 2025-03-28 | — | — | CN | disclosed |
| CN-119709892-A | Method for preparing (S) -2-hydroxy-3, 3-dimethylbutyric acid by using enzymatic method | 尚科生物医药（上海）有限公司 | 2025-03-28 | — | — | CN | disclosed |
| US-20240383876-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2024-11-21 | — | — | US | disclosed |
| EP-2318419-B2 | BORONATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | TAKEDA PHARMACEUTICALS CO (JP) | 2024-10-30 | — | — | EP | disclosed |
| CN-116818930-A | Chiral detection method of (S) - (-) -2-hydroxy-3, 3-dimethylbutyric acid | 上海吉奉生物科技有限公司 | 2023-09-29 | — | — | CN | disclosed |
| WO-2000031064-A1 | ENANTIOSELECTIVE ALKYLATION OF TRICYCLIC COMPOUNDS | SCHERING CORPORATION (US) | 2000-06-02 | — | — | WO | disclosed |
| US-5776933-A | Method of inhibiting protease | E. R. SQUIBB & SONS, INC. (US) | 1998-07-07 | — | — | US | disclosed |
| US-5760036-A | ENZYME INHIBITORS OF RETROVIRAL PROTEASE FOR PREVENTION OF AIDS | E. R. SQUIBB & SONS, INC. (US) | 1998-06-02 | — | — | US | disclosed |
| US-5559256-A | Aminediol protease inhibitors | E. R. SQUIBB & SONS, INC. (US) | 1996-09-24 | — | — | US | disclosed |
| CN-1085546-A | Aminediol protease inhibitors | SQUIBB & SONS INC (US) | 1994-04-20 | — | — | CN | disclosed |
| EP-0580402-A2 | Aminediol protease inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1994-01-26 | — | — | EP | disclosed |