SCHEMBL6401893

SCHEMBL6401893

COC(=O)c1ccccc1NC(=O)c1ccc(Oc2ccc3ccccc3c2)c(N)c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.57
ALDH1A1 P00352 2/20 0.57
ALOX12 P18054 1/20 0.57
TSHR P16473 3/20 0.53
HSD17B10 Q99714 2/20 0.53
MAPT P10636 3/20 0.51
MEN1 O00255 2/20 0.51
POLB P06746 2/20 0.51
KMT2A Q03164 2/20 0.51
GAA P10253 2/20 0.51
CYP1A2 P05177 1/20 0.51
CYP2D6 P10635 1/20 0.51
CYP2C19 P33261 1/20 0.51
ELANE P08246 1/20 0.51
PRTN3 P24158 1/20 0.51
LMNA P02545 1/20 0.51
TP53 P04637 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
PDE5A O76074 1/20 0.50
RAB9A P51151 5/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6404244 0.89 DHODH (0.56) KDM4EALDH1A1MEN1KMT2ARAB9A
SCHEMBL6410492 0.85 TSHR (0.62) KDM4EALDH1A1ALOX12TSHRHSD17B10
SCHEMBL21446855 0.84 KDM4E (0.77) KDM4EALDH1A1ALOX12TSHRHSD17B10
SCHEMBL6403580 0.84 ALDH1A1 (0.53) KDM4EALDH1A1ALOX12TSHRHSD17B10
SCHEMBL6339040 0.79 ELANE (0.62) KDM4EALDH1A1ALOX12TSHRHSD17B10
SCHEMBL266327 0.75 CHEK1 (0.80) KDM4EALDH1A1TSHRHSD17B10MAPT
SCHEMBL7230026 0.75 SIRT2 (0.72) KDM4EALDH1A1ALOX12TSHRHSD17B10
SCHEMBL4829005 0.75 KDM4E (0.63) KDM4EALDH1A1ALOX12TSHRHSD17B10
SCHEMBL6336997 0.74 MAPT (0.66) KDM4EALDH1A1TSHRHSD17B10MAPT
SCHEMBL11045073 0.74 F10 (0.77) KDM4EALDH1A1TSHRHSD17B10MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050027008-A1 Cancer remedy comprising anthranilic acid derivatives as active ingredient TEIJIN LIMITED 2005-02-03 US disclosed
US-20030220402-A1 Cancer remedy comprising anthranilic acid derivatives as active ingredients TEIJIN LIMITED (JP) 2003-11-27 US disclosed
EP-1256341-A1 CANCER REMEDY COMPRISING ANTHRANILIC ACID DERIVATIVE AS ACTIVE INGREDIENT TEIJIN LIMITED (JP) 2002-11-13 EP disclosed
CN-1048239-C Naphthalene deriv. TEIJIN LTD (JP) 2000-01-12 CN disclosed
CN-1153511-A Naphthalene deriv. TEIJIN LTD (JP) 1997-07-02 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030220402-A1 Cancer remedy comprising anthranilic acid derivatives as active ingredients HCCS, BCOR, CBR1 KDM4E 1406/4885ALDH1A1 1126/4885ALOX12 339/4885
US-20050027008-A1 Cancer remedy comprising anthranilic acid derivatives as active ingredient CA9, HCCS, CA7 KDM4E 1879/4885ALDH1A1 1389/4885ALOX12 297/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.