Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.42 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.42 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6396582 | 0.83 | ALDH1A1 (0.53) | ALDH1A1NPSR1HPGDKDM4EMAPT | |
| SCHEMBL6400955 | 0.83 | SOS1 (0.60) | ALDH1A1HTTHPGDKDM4EMAPT | |
| SCHEMBL2056342 | 0.77 | ALDH1A1 (0.62) | ALDH1A1NPSR1HTTHPGDKDM4E | |
| SCHEMBL7977954 | 0.77 | ALDH1A1 (0.73) | ALDH1A1NPSR1HTTHPGDKDM4E | |
| Hydrochloric Acid SCHEMBL11623836 | 0.76 | PYCR1 (0.55) | ALDH1A1NPSR1HTTHPGDKDM4E | |
| SCHEMBL11621135 | 0.74 | ALDH1A1 (0.65) | ALDH1A1NPSR1HTTHPGDKDM4E | |
| SCHEMBL6395900 | 0.74 | ALDH1A1 (0.46) | ALDH1A1NPSR1HTTHPGDKDM4E | |
| SCHEMBL5963771 | 0.74 | MEN1 (0.46) | ALDH1A1NPSR1HTTHPGDKDM4E | |
| SCHEMBL11452978 | 0.73 | ALDH1A1 (0.60) | ALDH1A1NPSR1HTTHPGDKDM4E | |
| SCHEMBL5536394 | 0.73 | ALDH1A1 (0.62) | ALDH1A1NPSR1HTTHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050059657-A1 | Aminoisoxazole derivatives active as kinase inhibitors | PFIZER ITALIA S.R.L. (IT) | 2005-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059657-A1 | Aminoisoxazole derivatives active as kinase inhibitors | MAP3K9, MAP3K19, MAP4K2 | ALDH1A1 4444/4885NPSR1 4399/4885HTT 2134/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.