Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STING1 | Q86WV6 | 8/20 | 0.49 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | RAPGEF3 | O95398 | 2/20 | 0.44 |
| ▸ | GMNN | O75496 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HINT1 | P49773 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.44 |
| ▸ | NT5E | P21589 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6398930 | 0.87 | STING1 (0.59) | STING1LMNAKMT2ARAPGEF3GMNN | |
| SCHEMBL1582124 | 0.87 | HINT1 (0.39) | STING1HSP90B1HINT1ADORA3NT5E | |
| SCHEMBL6395562 | 0.83 | STING1 (0.63) | STING1PDE3BPDE3A | |
| SCHEMBL5963100 | 0.82 | STING1 (0.47) | STING1HSP90B1LMNAKMT2ARAPGEF3 | |
| SCHEMBL12806732 | 0.80 | PDE4A (0.46) | STING1LMNAKMT2ARAPGEF3GMNN | |
| SCHEMBL12936600 | 0.80 | STING1 (0.61) | STING1 | |
| SCHEMBL12936674 | 0.80 | STING1 (0.61) | STING1 | |
| SCHEMBL16707282 | 0.75 | RXFP1 (0.42) | STING1LMNAKMT2ARAPGEF3GMNN | |
| SCHEMBL12803683 | 0.75 | RXFP1 (0.42) | STING1LMNAKMT2ARAPGEF3GMNN | |
| SCHEMBL12936667 | 0.75 | RXFP1 (0.42) | STING1LMNAKMT2ARAPGEF3GMNN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501830-A1 | 7-ARYL-3,9-DIAZABICYCLO[3.3.1]NON-6-ENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS IN THE TREATMENT OF HYPERTENSION, CARDIOVASCULAR OR RENAL DISEASES | Actelion Pharmaceuticals Ltd. (CH) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003093267-A1 | 7-ARYL-3,9-DIAZABICYCLO(3.3.1)NON-6-ENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS IN THE TREATMENT OF HYPERTENSION, CARDIOVASCULAR OR RENAL DISEASES | ACTELION PHARMACEUTICALS LTD (CH) | 2003-11-13 | — | — | WO | disclosed |