Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 2/20 | 1.00 |
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6404693 | 0.88 | BDKRB1 (0.78) | BDKRB1MAPTMAPK1ALDH1A1POLB | |
| SCHEMBL4427205 | 0.88 | BDKRB1 (0.78) | BDKRB1MAPTMAPK1ALDH1A1POLB | |
| SCHEMBL4432052 | 0.86 | ALDH1A1 (0.76) | BDKRB1MAPTMAPK1ALDH1A1POLB | |
| SCHEMBL6698072 | 0.84 | BDKRB1 (0.73) | BDKRB1MAPTMAPK1ALDH1A1POLB | |
| SCHEMBL4425413 | 0.81 | BDKRB1 (0.68) | BDKRB1MAPK1ALDH1A1POLBMEN1 | |
| SCHEMBL4420739 | 0.81 | BDKRB1 (0.68) | BDKRB1MAPK1ALDH1A1POLBMEN1 | |
| SCHEMBL6712062 | 0.80 | BDKRB1 (0.67) | BDKRB1MAPK1ALDH1A1POLBMEN1 | |
| SCHEMBL4431101 | 0.80 | BDKRB1 (0.67) | BDKRB1ALDH1A1POLBKDM4EHPGD | |
| SCHEMBL6406112 | 0.80 | BDKRB1 (0.67) | BDKRB1ALDH1A1POLBKDM4EHPGD | |
| SCHEMBL4422565 | 0.80 | BDKRB1 (0.67) | BDKRB1ALDH1A1POLBKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050020591-A1 | 2-Quinoxalinone derivatives as bradykinin antagonists and novel compounds | SU DAI-SHI (US) | 2005-01-27 | — | — | US | claimed |
| US-20050020591-A1 | 2-Quinoxalinone derivatives as bradykinin antagonists and novel compounds | SU DAI-SHI (US) | 2005-01-27 | — | — | US | disclosed |
| US-20040235849-A1 | Tetrahydroquinoxalines acting as bradykinin antagonists | BAYER HEALTHCARE AG (DE) | 2004-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040235849-A1 | Tetrahydroquinoxalines acting as bradykinin antagonists | BDKRB2, BDKRB1, LTB4R2 | BDKRB1 2/4885MAPT 3174/4885MAPK1 926/4885 |
| US-20050020591-A1 | 2-Quinoxalinone derivatives as bradykinin antagonists and novel compounds | BDKRB1, BDKRB2, LTB4R2 | BDKRB1 1/4885MAPT 3668/4885MAPK1 352/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.