SCHEMBL6402964

SCHEMBL6402964

CCCC1CCC(C2CCC(C(F)(F)Oc3cc(F)c(F)c(F)c3)CC2)CC1

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TLR4 O00206 1/20 0.32
SCN9A Q15858 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6402958 1.00 TLR4 (0.32) TLR4SCN9A
SCHEMBL18032048 1.00 TLR4 (0.32) TLR4SCN9A
SCHEMBL6402962 1.00 TLR4 (0.32) TLR4SCN9A
SCHEMBL20118270 0.96 SCN9A (0.32) SCN9A
SCHEMBL12032287 0.95 TLR4 (0.34) TLR4
SCHEMBL17070280 0.95
SCHEMBL12032062 0.95 TLR4 (0.34) TLR4
SCHEMBL18032114 0.93
SCHEMBL14226681 0.93
SCHEMBL18032047 0.93

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 273 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3810724-B1 LIQUID-CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2023-11-22 EP disclosed
US-10865344-B2 Low molecular weight polar compound for homogeneously aligning liquid crystal medium, and liquid crystal medium containing same JNC CORPORATION (JP) 2020-12-15 US disclosed
US-10788715-B2 Photo-alignment material and photo-alignment method TOKYO INSTITUTE OF TECHNOLOGY (JP) 2020-09-29 US disclosed
US-10787608-B2 Liquid crystal display device including liquid crystal medium containing low molecular weight polar compound for homogeneously aligning liquid crystal medium JNC CORPORATION (JP) 2020-09-29 US disclosed
US-10723947-B2 Liquid crystal composition and liquid crystal display device thereof JIANGSU HECHENG DISPLAY TECHNOLOGY CO., LTD. (CN) 2020-07-28 US disclosed
EP-2808375-B1 LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY ELEMENT PRODUCED USING SAME DAINIPPON INK & CHEMICALS (JP) 2020-01-22 EP disclosed
US-10457869-B2 Liquid crystal composition and liquid crystal display device JIANGSU HECHENG DISPLAY TECHNOLOGY CO., LTD. (CN) 2019-10-29 US disclosed
US-20190292462-A1 LIQUID CRYSTAL DISPLAY DEVICE INCLUDING LIQUID CRYSTAL MEDIUM CONTAINING LOW MOLECULAR WEIGHT POLAR COMPOUND FOR HOMOGENEOUSLY ALIGNING LIQUID CRYSTAL MEDIUM JNC CORPORATION (JP) 2019-09-26 US disclosed
US-20190292455-A1 LOW MOLECULAR WEIGHT POLAR COMPOUND FOR HOMOGENEOUSLY ALIGNING LIQUID CRYSTAL MEDIUM, AND LIQUID CRYSTAL MEDIUM CONTAINING SAME JNC CORPORATION (JP) 2019-09-26 US disclosed
US-10421907-B2 Liquid crystal composition and a liquid crystal display including the same SAMSUNG DISPLAY CO., LTD. (KR) 2019-09-24 US disclosed
US-6827876-B2 Using alpha, alpha -difluorocyclohexylidene derivative as starting material to obtain difluoromethyl ether derivative CHISSO CORPORATION (JP) 2004-12-07 US disclosed
US-20040016906-A1 Difluoromethyl ether derivative and process for producing the same JNC CORPORATION (JP) 2004-01-29 US disclosed
US-20040004207-A1 Difluoromethyl ether derivative and process for producing the same JNC CORPORATION (JP) 2004-01-08 US disclosed
US-6605747-B2 Reacting the starting material, an alpha , alpha -difluorocyclohexylidene derivative with a halogen to produce an intermediate, reacting the intermediate with a phenol compound in presence of a base CHISSO CORPORATION (JP) 2003-08-12 US disclosed
US-20020120168-A1 Difluoromethyl ether derivative and process for producing the same JNC PETROCHEMICAL CORPORATION (JP) 2002-08-29 US disclosed
EP-1182186-A2 Difluoromethyl ether derivative and process for producing the same CHISSO CORPORATION (JP) 2002-02-27 EP disclosed
EP-0844229-B1 Polyhaloalkyl ether derivatives as well as liquid crystal compositions and liquid crystal display elements containing them CHISSO CORP (JP) 2002-02-06 EP disclosed
EP-1029842-A2 Polyhaloalkyl ether derivatives as well as liquid crystal compositions and liquid crystal display elements containing them CHISSO CORPORATION (JP) 2000-08-23 EP disclosed
US-6007740-A USED PARTICULARLY TO LOWER THRESHOLD VOLTAGE OF LIQUID CRYSTAL COMPOSITIONS, TO ENLARGE A NEMATIC RANGE, SUCH AS INCREASE IN CLEAR POINT OF LIQUID CRYSTAL COMPOSITIONS AND CONTROL REFRACTIVE ANISOTROPIC VALUE CHISSO CORPORATION (JP) 1999-12-28 US disclosed
EP-0844229-A1 Polyhaloalkyl ether derivatives as well as liquid crystal compositions and liquid crystal display elements containing them CHISSO CORPORATION (JP) 1998-05-27 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040004207-A1 Difluoromethyl ether derivative and process for producing the same RCC1, PYM1, SCFD1 TLR4 2836/4885SCN9A 2152/4885
US-10787608-B2 Liquid crystal display device including liquid crystal medium containing low molecular weight polar compound for homogeneously aligning liquid crystal medium ACP1, MAPK1, PLD1 TLR4 3809/4885SCN9A 2922/4885
US-20040016906-A1 Difluoromethyl ether derivative and process for producing the same RCC1, SCFD1, AFF1 TLR4 2836/4885SCN9A 2082/4885
US-20020120168-A1 Difluoromethyl ether derivative and process for producing the same LEF1, AFF1, RCC1 TLR4 2989/4885SCN9A 2250/4885
US-10421907-B2 Liquid crystal composition and a liquid crystal display including the same CCDC22, LRRK2, ZKSCAN2 TLR4 4762/4885SCN9A 3138/4885
US-20190292462-A1 LIQUID CRYSTAL DISPLAY DEVICE INCLUDING LIQUID CRYSTAL MEDIUM CONTAINING LOW MOLECULAR WEIGHT POLAR COMPOUND FOR HOMOGENEOUSLY ALIGNING LIQUID CRYSTAL MEDIUM ACP1, MAPK1, PLD1 TLR4 3809/4885SCN9A 2922/4885
US-10865344-B2 Low molecular weight polar compound for homogeneously aligning liquid crystal medium, and liquid crystal medium containing same ACP1, MFAP1, PHOSPHO1 TLR4 4693/4885SCN9A 3626/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.