Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 19/20 | 0.59 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6403150 | 1.00 | P2RX7 (0.59) | P2RX7KCNJ11ALDH1A1 | |
| SCHEMBL6401857 | 0.92 | P2RX7 (0.70) | P2RX7ALDH1A1 | |
| SCHEMBL6401859 | 0.92 | P2RX7 (0.70) | P2RX7ALDH1A1 | |
| SCHEMBL6403143 | 0.90 | P2RX7 (0.56) | P2RX7KCNJ11ALDH1A1 | |
| SCHEMBL6403147 | 0.90 | P2RX7 (0.56) | P2RX7KCNJ11ALDH1A1 | |
| SCHEMBL6400149 | 0.89 | P2RX7 (0.71) | P2RX7ALDH1A1 | |
| SCHEMBL6400150 | 0.89 | P2RX7 (0.71) | P2RX7ALDH1A1 | |
| SCHEMBL6406819 | 0.87 | P2RX7 (0.72) | P2RX7 | |
| SCHEMBL6406309 | 0.87 | P2RX7 (0.72) | P2RX7 | |
| SCHEMBL6408756 | 0.86 | P2RX7 (0.67) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050171195-A1 | P2X7 antagonists for treating neuropathic pain | ABBOTT LABORATORIES | 2005-08-04 | — | — | US | claimed |
| US-20050171195-A1 | P2X7 antagonists for treating neuropathic pain | ABBOTT LABORATORIES | 2005-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050171195-A1 | P2X7 antagonists for treating neuropathic pain | P2RX3, P2RX7, P2RX1 | P2RX7 2/4885KCNJ11 59/4885ALDH1A1 1730/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.