Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 4/20 | 0.35 |
| ▸ | NR2F2 | P24468 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | FLT3 | P36888 | 2/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.34 |
| ▸ | PEAK1 | Q9H792 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | CCNK | O75909 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | FLT1 | P17948 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6332610 | 0.83 | PKM (0.39) | PKMNPC1ALDH1A1KMT2AGAA | |
| SCHEMBL6332611 | 0.83 | PKM (0.39) | PKMNPC1ALDH1A1KMT2AGAA | |
| SCHEMBL6408653 | 0.75 | PI4KB (0.40) | NPC1KMT2ABRAFMAPTL3MBTL1 | |
| SCHEMBL6334518 | 0.74 | STAT3 (0.51) | NPC1HTTALDH1A1LMNATP53 | |
| SCHEMBL6402827 | 0.72 | PKM (0.37) | PKMNPC1HTTALDH1A1LMNA | |
| SCHEMBL6405533 | 0.70 | PKM (0.37) | PKMALDH1A1STAT3NR2F2KMT2A | |
| SCHEMBL6405526 | 0.70 | PKM (0.37) | PKMALDH1A1STAT3NR2F2KMT2A | |
| SCHEMBL6502783 | 0.70 | CDK2 (0.46) | NPC1HTTALDH1A1LMNATP53 | |
| SCHEMBL6404299 | 0.69 | BRAF (0.37) | PKMNPC1ALDH1A1LMNAKMT2A | |
| SCHEMBL6533769 | 0.67 | PI4KB (0.39) | ALDH1A1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6969713-B2 | Piperidine and piperazine acetamide derivatives | ASTRAZENECA AB (SE) | 2005-11-29 | — | — | US | disclosed |
| US-20030013721-A1 | Novel piperidine and piperazine derivatives | ASTRAZENECA AB (SE) | 2003-01-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030013721-A1 | Novel piperidine and piperazine derivatives | IL5, VIP, EP300 | PKM 658/4885NPC1 87/4885HTT 2520/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.