Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KB | Q9UBF8 | 4/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.34 |
| ▸ | WNT3A | P56704 | 2/20 | 0.32 |
| ▸ | SIRT3 | Q9NTG7 | 3/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.31 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6408653 | 0.92 | PI4KB (0.40) | PI4KBS1PR1WNT3ADPP4KMT2A | |
| SCHEMBL6336265 | 0.79 | PI4KB (0.43) | PI4KBMEN1KMT2AATMALDH1A1 | |
| SCHEMBL6404299 | 0.76 | BRAF (0.37) | S1PR1WNT3AMEN1KMT2AATM | |
| SCHEMBL6531850 | 0.74 | P2RX7 (0.44) | MEN1KMT2AATMALDH1A1SMN1; SMN2 | |
| SCHEMBL6332610 | 0.72 | PKM (0.39) | WNT3AMEN1KMT2AATMALDH1A1 | |
| SCHEMBL6408660 | 0.70 | PSMD14 (0.32) | MEN1KMT2AATMALDH1A1SMN1; SMN2 | |
| SCHEMBL6489583 | 0.64 | HPGD (0.45) | KMT2ASMN1; SMN2 | |
| SCHEMBL6408514 | 0.63 | KDM4E (0.36) | WNT3AMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL6335936 | 0.62 | MEN1 (0.44) | MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL6502783 | 0.62 | CDK2 (0.46) | S1PR1MEN1KMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272745-A1 | Novel piperidine and piperazine derivatives | ASTRAZENECA AB | 2005-12-08 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050272745-A1 | Novel piperidine and piperazine derivatives | CYP3A5, IL5, ABCC5 | PI4KB 3088/4885S1PR1 396/4885WNT3A 4168/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.