Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.53 |
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.42 |
| ▸ | KDR | P35968 | 5/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 5/20 | 0.41 |
| ▸ | RET | P07949 | 4/20 | 0.41 |
| ▸ | FLT3 | P36888 | 3/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.41 |
| ▸ | FLT1 | P17948 | 2/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | TLK2 | Q86UE8 | 3/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6391361 | 1.00 | SIRT1 (0.53) | SIRT1MAP4K1PDGFRBKDRFGFR1 | |
| SCHEMBL1538367 | 0.82 | KDR (0.59) | SIRT1MAP4K1PDGFRBKDRFGFR1 | |
| SCHEMBL2768013 | 0.82 | KDR (0.59) | SIRT1MAP4K1PDGFRBKDRFGFR1 | |
| SCHEMBL6389448 | 0.82 | KDR (0.58) | SIRT1MAP4K1PDGFRBKDRFGFR1 | |
| SCHEMBL6389451 | 0.82 | KDR (0.58) | SIRT1MAP4K1PDGFRBKDRFGFR1 | |
| SCHEMBL6389284 | 0.82 | LRRK2 (0.62) | SIRT1MAP4K1PDGFRBRETLRRK2 | |
| SCHEMBL6390271 | 0.82 | RET (0.62) | SIRT1MAP4K1PDGFRBKDRFGFR1 | |
| SCHEMBL6390272 | 0.82 | RET (0.62) | SIRT1MAP4K1PDGFRBKDRFGFR1 | |
| SCHEMBL6389287 | 0.82 | LRRK2 (0.62) | SIRT1MAP4K1PDGFRBRETLRRK2 | |
| SCHEMBL6395710 | 0.79 | TLK2 (0.64) | SIRT1MAP4K1PDGFRBKDRFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6855730-B2 | 3-methylidenyl-2-indolinone modulators of protein kinase | SUGEN, INC. (US) | 2005-02-15 | — | — | US | disclosed |
| US-20040024010-A1 | 3-methylidenyl-2-indolinone modulators of protein kinase | SUGEN, INC. | 2004-02-05 | — | — | US | disclosed |
| US-6680335-B2 | FOR THERAPY AND PROPHYLAXIS OF CANCER, HYPERTENSION, DEPRESSION, GENERALIZED ANXIETY DISORDER, PHOBIAS, POST-TRAUMATIC STRESS SYNDROME, AVOIDANT PERSONALITY DISORDER, SEXUAL DYSFUNCTION, EATING DISORDERS, OBESITY | SUGEN, INC. | 2004-01-20 | — | — | US | disclosed |
| US-6531502-B1 | Antitumor | SUGEN, INC. | 2003-03-11 | — | — | US | disclosed |
| US-20020183364-A1 | Methods of modulating protein tyrosine kinase function with substituted indolinone compounds | SUGEN, INC. | 2002-12-05 | — | — | US | disclosed |
| WO-2000008202-A9 | 3-METHYLIDENYL-2-INDOLINONE MODULATORS OF PROTEIN KINASE | SUGEN INC (US) | 2000-07-27 | — | — | WO | disclosed |
| WO-2000008202-A2 | 3-METHYLIDENYL-2-INDOLINONE MODULATORS OF PROTEIN KINASE | SUGEN, INC. (US) | 2000-02-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040024010-A1 | 3-methylidenyl-2-indolinone modulators of protein kinase | DMPK, MAP4K3, MAP3K20 | SIRT1 1404/4885MAP4K1 10/4885PDGFRB 1860/4885 |
| US-20020183364-A1 | Methods of modulating protein tyrosine kinase function with substituted indolinone compounds | PNCK, CAMK4, CAMK1 | SIRT1 2432/4885MAP4K1 36/4885PDGFRB 727/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.