SCHEMBL6404572

SCHEMBL6404572

Nc1cccc(-c2nc3c(N)cccc3o2)c1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 12/20 0.60
RAB9A P51151 12/20 0.55
SMN1; SMN2 Q16637 8/20 0.55
KDM4E B2RXH2 6/20 0.55
MAPT P10636 6/20 0.55
ALDH1A1 P00352 5/20 0.55
HPGD P15428 5/20 0.55
NFKB1 P19838 1/20 0.55
NFKB2 Q00653 1/20 0.55
RELA Q04206 1/20 0.55
KMT2A Q03164 5/20 0.51
MEN1 O00255 4/20 0.51
GAA P10253 2/20 0.51
CACNA1B Q00975 1/20 0.51
APBA1 Q02410 1/20 0.51
MECP2 P51608 1/20 0.50
TP53 P04637 2/20 0.48
HSD17B10 Q99714 2/20 0.48
HIF1A Q16665 1/20 0.46
KDM1A O60341 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30597434 1.00 NPC1 (0.60) NPC1RAB9ASMN1; SMN2KDM4EMAPT
SCHEMBL31433078 0.85 RAB9A (0.53) NPC1RAB9ASMN1; SMN2KDM4EMAPT
SCHEMBL7109574 0.85 RAB9A (0.53) NPC1RAB9ASMN1; SMN2KDM4EMAPT
SCHEMBL10825753 0.84 NPC1 (0.51) NPC1RAB9ASMN1; SMN2KDM4EMAPT
SCHEMBL31631310 0.84 NPC1 (0.57) NPC1RAB9ASMN1; SMN2KDM4EMAPT
SCHEMBL6399187 0.83 NPC1 (0.60) NPC1RAB9ASMN1; SMN2KDM4EMAPT
SCHEMBL28592600 0.82 NPC1 (0.60) NPC1RAB9ASMN1; SMN2KDM4EMAPT
SCHEMBL4904649 0.81 KDM4E (0.59) NPC1RAB9ASMN1; SMN2KDM4EMAPT
SCHEMBL206178 0.80 PARP1 (0.54) NPC1RAB9ASMN1; SMN2KDM4EMAPT
SCHEMBL760587 0.79 NPC1 (0.68) NPC1RAB9ASMN1; SMN2KDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050170077-A1 Adhesion method SHIPLEY COMPANY, L.L.C. (US) 2005-08-04 US disclosed
US-20040161545-A1 Adhesion method SHIPLEY COMPANY, L.L.C. 2004-08-19 US disclosed
US-6222044-B1 REACTING AN AROMATIC ALDEHYDE WITH HYDROXYLAMINE TO FORM AN AROMATIC ALDEHYDE OXIME, HALOGENATING OXIME TO FORM AROMATIC HYDROXAMOYL HALIDE, AND REACTING WITH AROMATIC AMINE COMPOUNDS TO FORM BENZOXAZOLE, BENZOTHIAXOLE, BENZIMIDAZOLES THE DOW CHEMICAL COMPANY 2001-04-24 US disclosed
EP-0820447-B1 PROCESS FOR MAKING 2-ARYL BENZ(OX, THI, IMID)AZOLES AND 2-AMINOARYL AMINOBENZ(OX, THI, IMID)AZOLES DOW CHEMICAL CO (US) 2000-08-23 EP disclosed
EP-0820447-A1 PROCESS FOR MAKING 2-ARYL BENZ(OX, THI, IMID)AZOLES AND 2-AMINOARYL AMINOBENZ(OX, THI, IMID)AZOLES THE DOW CHEMICAL COMPANY (US) 1998-01-28 EP disclosed
US-5567843-A Process for making 2-aryl benz (ox, thi, imid)azoles and 2-aminoaryl aminobenz(ox, thi, imid)azoles THE DOW CHEMICAL COMPANY (US) 1996-10-22 US disclosed
WO-1996029319-A1 PROCESS FOR MAKING 2-ARYL BENZ(OX, THI, IMID)AZOLES AND 2-AMINOARYL AMINOBENZ(OX, THI, IMID)AZOLES THE DOW CHEMICAL COMPANY (US) 1996-09-26 WO disclosed
EP-0464371-A1 Polyamic acid structures, and methods of fabrication thereof International Business Machines Corporation (US) 1992-01-08 EP disclosed
US-5004627-A Polyimides for mold release ETHYL CORPORATION (US) 1991-04-02 US disclosed
EP-0192937-B1 FLEXIBLE POLYIMIDE MULTILAYER LAMINATE Akzo Patente GmbH (DE) 1990-10-24 EP disclosed
EP-0249744-A1 Process for making polyimide-metal laminates AKZO N.V. (NL) 1987-12-23 EP disclosed
EP-0116297-B1 POLYIMIDE LAMINATE WITH PEEL-RESISTANCE AND METHOD OF MANUFACTURING IT Akzo GmbH (DE) 1987-12-02 EP disclosed
US-4705720-A FOR PRINTED CIRCUITS AKZO NV (NL) 1987-11-10 US disclosed
US-4699841-A PRINTED CIRCUITS AKZO NV (NL) 1987-10-13 US disclosed
US-4675246-A DIRECT BONDING WITH SUBSTRATE AND POLYIMIDE AKZO NV (NL) 1987-06-23 US disclosed
EP-0194413-A2 Printed circuit element with a cover sheet containing polyimide Akzo Patente GmbH (DE) 1986-09-17 EP disclosed
EP-0192937-A2 Flexible polyimide multilayer laminate Akzo Patente GmbH (DE) 1986-09-03 EP disclosed
EP-0167020-A2 Flexible polyimide multilayer laminate Akzo Patente GmbH (DE) 1986-01-08 EP disclosed
US-4522880-A EXTRUSION ON SUBSTRATE, THEN CURING AKZONA INCORPORATED (US) 1985-06-11 US disclosed
EP-0116297-A2 Polyimide laminate with peel-resistance and method of manufacturing it Akzo GmbH (DE) 1984-08-22 EP disclosed