Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.76 |
| ▸ | GRIN2B | Q13224 | 11/20 | 0.74 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.74 |
| ▸ | DRD2 | P14416 | 2/20 | 0.71 |
| ▸ | DRD3 | P35462 | 2/20 | 0.71 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.57 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.54 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6404851 | 1.00 | POLB (0.76) | POLBKMT2AGRIN2BGRIN1DRD2 | |
| SCHEMBL388869 | 0.88 | POLB (0.65) | POLBKMT2AGRIN2BGRIN1DRD2 | |
| SCHEMBL355042 | 0.88 | DRD2 (0.67) | POLBKMT2AGRIN2BGRIN1DRD2 | |
| SCHEMBL9516292 | 0.88 | DRD2 (0.67) | POLBKMT2AGRIN2BGRIN1DRD2 | |
| SCHEMBL9515249 | 0.88 | DRD2 (0.67) | POLBKMT2AGRIN2BGRIN1DRD2 | |
| Hydrochloric Acid SCHEMBL9305508 | 0.86 | DRD2 (0.65) | POLBKMT2AGRIN2BGRIN1DRD2 | |
| Hydrochloric Acid SCHEMBL8767433 | 0.86 | DRD2 (0.65) | POLBKMT2AGRIN2BGRIN1DRD2 | |
| Hydrochloric Acid SCHEMBL9304463 | 0.86 | DRD2 (0.65) | POLBKMT2AGRIN2BGRIN1DRD2 | |
| Hydrochloric Acid SCHEMBL7326528 | 0.85 | POLB (0.97) | POLBKMT2AGRIN2BGRIN1DRD2 | |
| Hydrochloric Acid SCHEMBL7335860 | 0.84 | POLB (0.74) | POLBKMT2AGRIN2BGRIN1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050153408-A1 | 7-substituted-2-tetralone or bisulfite adduct is reduced microorganism (Candida) to optically active 7-substituted-2-tetralol;sulfonyl group is introduced to hydroxy group to form optically active 7-substituted-2-sulfonyloxytetralin; nitrogen substituent is introduced via ammonia; industrial scale | KANEKA CORPORATION (JP) | 2005-07-14 | — | — | US | disclosed |
| EP-1457570-A1 | PROCESS FOR PREPARATION OF 2-AMINOTETRALIN DERIVATIVES AND INTERMEDIATES THEREOF | KANEKA CORPORATION (JP) | 2004-09-15 | — | — | EP | disclosed |