Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 12/20 | 0.64 |
| ▸ | NR1H3 | Q13133 | 10/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 7/20 | 0.34 |
| ▸ | PPARD | Q03181 | 7/20 | 0.34 |
| ▸ | PPARG | P37231 | 6/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6404754 | 0.88 | NR1H2 (0.48) | NR1H2NR1H3GRM2PPARAPPARD | |
| SCHEMBL6408328 | 0.85 | NR1H2 (0.46) | NR1H2NR1H3GRM2PPARAPPARD | |
| SCHEMBL6405354 | 0.85 | NR1H2 (0.72) | NR1H2NR1H3PPARAPPARDPPARG | |
| SCHEMBL6097922 | 0.84 | NR1H2 (0.74) | NR1H2NR1H3GRM2PPARAPPARD | |
| SCHEMBL6405513 | 0.83 | NR1H2 (0.44) | NR1H2NR1H3GRM2PPARAPPARD | |
| SCHEMBL6407458 | 0.81 | NR1H2 (0.41) | NR1H2NR1H3ALDH1A1GRM2PPARA | |
| SCHEMBL6100435 | 0.78 | NR1H2 (1.00) | NR1H2NR1H3PPARAPPARDPPARG | |
| SCHEMBL6411684 | 0.77 | NR1H2 (0.57) | NR1H2NR1H3ALDH1A1 | |
| SCHEMBL6405323 | 0.72 | NR1H2 (0.55) | NR1H2NR1H3PPARAPPARDPPARG | |
| SCHEMBL1595776 | 0.72 | NR1H2 (0.71) | NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534696-A1 | THERAPEUTIC COMPOUNDS FOR TREATING DYSLIPIDEMIC CONDITIONS | Merck & Co., Inc. (US) | 2005-06-01 | — | — | EP | claimed |
| WO-2004011448-A1 | THERAPEUTIC COMPOUNDS FOR TREATING DYSLIPIDEMIC CONDITIONS | MERCK & CO., INC. (US) | 2004-02-05 | — | — | WO | claimed |
| EP-1534696-A1 | THERAPEUTIC COMPOUNDS FOR TREATING DYSLIPIDEMIC CONDITIONS | Merck & Co., Inc. (US) | 2005-06-01 | — | — | EP | disclosed |
| WO-2004011448-A1 | THERAPEUTIC COMPOUNDS FOR TREATING DYSLIPIDEMIC CONDITIONS | MERCK & CO., INC. (US) | 2004-02-05 | — | — | WO | disclosed |