Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 12/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 11/20 | 0.41 |
| ▸ | PPARA | Q07869 | 9/20 | 0.37 |
| ▸ | PPARG | P37231 | 7/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 8/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PGK1 | P00558 | 1/20 | 0.34 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6404754 | 0.86 | NR1H2 (0.48) | NR1H2NR1H3PPARAPPARGGRM2 | |
| SCHEMBL6406097 | 0.85 | NR1H2 (0.47) | NR1H2NR1H3PPARAPPARGPPARD | |
| SCHEMBL6405614 | 0.84 | NR1H2 (0.47) | NR1H2NR1H3PPARAPPARGPPARD | |
| SCHEMBL6098935 | 0.84 | GRM2 (0.52) | NR1H2NR1H3PPARAPPARGGRM2 | |
| SCHEMBL6408328 | 0.81 | NR1H2 (0.46) | NR1H2NR1H3PPARAPPARGGRM2 | |
| SCHEMBL6405846 | 0.81 | NR1H2 (0.64) | NR1H2NR1H3PPARAPPARGGRM2 | |
| SCHEMBL6099203 | 0.78 | NR1H3 (0.67) | NR1H2NR1H3PPARAPPARGPPARD | |
| SCHEMBL6102250 | 0.77 | NR1H3 (0.66) | NR1H2NR1H3PPARAPPARGPPARD | |
| SCHEMBL6405513 | 0.77 | NR1H2 (0.44) | NR1H2NR1H3PPARAPPARGGRM2 | |
| SCHEMBL6411684 | 0.74 | NR1H2 (0.57) | NR1H2NR1H3ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534696-A1 | THERAPEUTIC COMPOUNDS FOR TREATING DYSLIPIDEMIC CONDITIONS | Merck & Co., Inc. (US) | 2005-06-01 | — | — | EP | claimed |
| WO-2004011448-A1 | THERAPEUTIC COMPOUNDS FOR TREATING DYSLIPIDEMIC CONDITIONS | MERCK & CO., INC. (US) | 2004-02-05 | — | — | WO | claimed |
| EP-1534696-A1 | THERAPEUTIC COMPOUNDS FOR TREATING DYSLIPIDEMIC CONDITIONS | Merck & Co., Inc. (US) | 2005-06-01 | — | — | EP | disclosed |
| WO-2004011448-A1 | THERAPEUTIC COMPOUNDS FOR TREATING DYSLIPIDEMIC CONDITIONS | MERCK & CO., INC. (US) | 2004-02-05 | — | — | WO | disclosed |