Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | SCD | O00767 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7196184 | 0.87 | L3MBTL1 (0.54) | KMT2AMEN1MAPK14L3MBTL1SMN1; SMN2 | |
| SCHEMBL6105158 | 0.85 | L3MBTL1 (0.54) | KMT2AMEN1MAPK14L3MBTL1SMN1; SMN2 | |
| SCHEMBL3597783 | 0.84 | KMT2A (0.61) | KMT2AMEN1POLBMAPK14L3MBTL1 | |
| Benzene SCHEMBL6488418 | 0.79 | MAPK14 (0.55) | KMT2AMEN1POLBMAPK14L3MBTL1 | |
| SCHEMBL1540156 | 0.78 | LCK (0.74) | KMT2AMEN1POLBALDH1A1HPGD | |
| SCHEMBL19724720 | 0.77 | ALDH1A1 (0.59) | KMT2AMEN1POLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL3577082 | 0.77 | ALDH1A1 (0.62) | KMT2AMEN1POLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL28508629 | 0.74 | ALDH1A1 (0.77) | KMT2AMEN1POLBL3MBTL1SMN1; SMN2 | |
| SCHEMBL3584809 | 0.73 | SCD (0.82) | KMT2AMEN1POLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL19724843 | 0.72 | SCD (0.66) | KMT2AMEN1POLBSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050288303-A1 | Orally administering N-(2-chloro-6-methylphenyl)-2-[4-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-6-ylamino]thiazole-5-carboxamide for treating cancer | BRISTOL-MYERS SQUIBB COMPANY | 2005-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288303-A1 | Orally administering N-(2-chloro-6-methylphenyl)-2-[4-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-6-ylamino]thiazole-5-carboxamide for treating cancer | LCK, ERBB2, JAK2 | KMT2A 353/4885MEN1 2840/4885POLB 3213/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.