Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 17/20 | 0.51 |
| ▸ | NR1H3 | Q13133 | 9/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6405303 | 0.86 | NR1H2 (0.65) | NR1H2NR1H3ALDH1A1GAA | |
| SCHEMBL6100079 | 0.86 | NR1H2 (0.54) | NR1H2NR1H3PPARGPPARA | |
| SCHEMBL6406340 | 0.79 | NR1H2 (0.56) | NR1H2NR1H3 | |
| SCHEMBL6406547 | 0.79 | NR1H2 (0.59) | NR1H2NR1H3PPARA | |
| SCHEMBL6407486 | 0.79 | NR1H2 (0.55) | NR1H2NR1H3 | |
| SCHEMBL6407509 | 0.77 | NR1H2 (0.52) | NR1H2NR1H3 | |
| SCHEMBL6405163 | 0.75 | NR1H2 (0.50) | NR1H2NR1H3ALDH1A1GAA | |
| SCHEMBL6410481 | 0.73 | NR1H2 (0.60) | NR1H2NR1H3ALDH1A1GAATP53 | |
| SCHEMBL6411684 | 0.73 | NR1H2 (0.57) | NR1H2NR1H3ALDH1A1GAATP53 | |
| SCHEMBL6405855 | 0.72 | NR1H2 (0.48) | NR1H2NR1H3PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534696-A1 | THERAPEUTIC COMPOUNDS FOR TREATING DYSLIPIDEMIC CONDITIONS | Merck & Co., Inc. (US) | 2005-06-01 | — | — | EP | claimed |
| WO-2004011448-A1 | THERAPEUTIC COMPOUNDS FOR TREATING DYSLIPIDEMIC CONDITIONS | MERCK & CO., INC. (US) | 2004-02-05 | — | — | WO | claimed |
| EP-1534696-A1 | THERAPEUTIC COMPOUNDS FOR TREATING DYSLIPIDEMIC CONDITIONS | Merck & Co., Inc. (US) | 2005-06-01 | — | — | EP | disclosed |
| WO-2004011448-A1 | THERAPEUTIC COMPOUNDS FOR TREATING DYSLIPIDEMIC CONDITIONS | MERCK & CO., INC. (US) | 2004-02-05 | — | — | WO | disclosed |