Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 4/20 | 0.48 |
| ▸ | PPARA | Q07869 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | FLT4 | P35916 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.39 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.39 |
| ▸ | ACLY | P53396 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 2/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL639914 | 0.83 | PPARG (0.47) | PPARGPPARAMEN1KMT2AFLT1 | |
| SCHEMBL641222 | 0.78 | PPARG (0.44) | PPARGPPARAMEN1KMT2AFLT1 | |
| SCHEMBL641531 | 0.77 | PPARG (0.56) | PPARGPPARAMEN1KMT2AFLT1 | |
| SCHEMBL640078 | 0.77 | RXFP1 (0.46) | PPARGPPARAMEN1KMT2AFLT1 | |
| SCHEMBL641506 | 0.77 | PPARG (0.45) | PPARGPPARAMEN1KMT2ARXFP1 | |
| SCHEMBL641120 | 0.76 | PPARG (0.43) | PPARGPPARAMEN1KMT2ARXFP1 | |
| SCHEMBL639656 | 0.76 | PPARG (0.43) | PPARGPPARAMEN1KMT2APTGS1 | |
| SCHEMBL641108 | 0.76 | MEN1 (0.43) | PPARGPPARAMEN1KMT2ARXFP1 | |
| SCHEMBL640146 | 0.75 | PPARG (0.45) | PPARGPPARAMEN1KMT2AFLT1 | |
| SCHEMBL640161 | 0.75 | PKM (0.44) | PPARGPPARAKMT2ARXFP1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8791148-B2 | Substituted benzimidazolone derivatives, medicaments comprising them and their use | AbbVie Deutschland GmbH & Co. KG (DE) | 2014-07-29 | — | — | US | disclosed |
| US-8119676-B2 | Substituted benzimidazolone derivatives, medicaments comprising them and their use | Abbott GmbH & Co. HG (DE) | 2012-02-21 | — | — | US | disclosed |