Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 4/20 | 0.45 |
| ▸ | PPARA | Q07869 | 4/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | PPARD | Q03181 | 2/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15891015 | 0.89 | CXCL8 (0.42) | PPARGPPARAMEN1KMT2AALDH1A1 | |
| SCHEMBL639914 | 0.76 | PPARG (0.47) | PPARGPPARARXFP1MEN1KMT2A | |
| SCHEMBL640650 | 0.75 | PPARG (0.48) | PPARGPPARARXFP1MEN1KMT2A | |
| SCHEMBL641531 | 0.74 | PPARG (0.56) | PPARGPPARARXFP1MEN1KMT2A | |
| SCHEMBL10143431 | 0.74 | NOD1 (0.53) | PPARGPPARAMEN1KMT2AALDH1A1 | |
| SCHEMBL641222 | 0.73 | PPARG (0.44) | PPARGPPARARXFP1MEN1KMT2A | |
| SCHEMBL639915 | 0.72 | PPARG (0.49) | PPARGPPARARXFP1MEN1KMT2A | |
| SCHEMBL640078 | 0.72 | RXFP1 (0.46) | PPARGPPARARXFP1MEN1KMT2A | |
| SCHEMBL641506 | 0.72 | PPARG (0.45) | PPARGPPARARXFP1MEN1KMT2A | |
| SCHEMBL639656 | 0.71 | PPARG (0.43) | PPARGPPARARXFP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8791148-B2 | Substituted benzimidazolone derivatives, medicaments comprising them and their use | AbbVie Deutschland GmbH & Co. KG (DE) | 2014-07-29 | — | — | US | disclosed |
| US-8119676-B2 | Substituted benzimidazolone derivatives, medicaments comprising them and their use | Abbott GmbH & Co. HG (DE) | 2012-02-21 | — | — | US | disclosed |