Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 6/20 | 0.38 |
| ▸ | MAP2K2 | P36507 | 4/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 5/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6207706 | 0.88 | ALDH1A1 (0.38) | PIM1CAMK2BFLT1ALDH1A1KDM4E | |
| SCHEMBL6400835 | 0.87 | DUSP3 (0.37) | PIM1CAMK2BFLT1ALDH1A1KDM4E | |
| SCHEMBL6404352 | 0.84 | MAP2K1 (0.41) | PIM1CAMK2BFLT1MAP2K1MAP2K2 | |
| SCHEMBL6208038 | 0.84 | PIM1 (0.45) | PIM1CAMK2BMAP2K1MAP2K2MAPK1 | |
| SCHEMBL6400824 | 0.84 | MAP2K1 (0.38) | PIM1CAMK2BFLT1ALDH1A1KDM4E | |
| SCHEMBL6187892 | 0.83 | MAP2K1 (0.45) | PIM1CAMK2BMAP2K1MAP2K2MAPK1 | |
| SCHEMBL6400821 | 0.83 | TP53 (0.40) | PIM1CAMK2BFLT1MAP2K1MAP2K2 | |
| SCHEMBL21067809 | 0.83 | MAP2K1 (0.46) | PIM1CAMK2BMAP2K1MAP2K2MAPK1 | |
| SCHEMBL6406299 | 0.83 | PIM1 (0.44) | PIM1CAMK2BALDH1A1KDM4EHPGD | |
| SCHEMBL6398520 | 0.82 | PIM1 (0.46) | PIM1CAMK2BMAP2K1MAP2K2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050004186-A1 | MEK inhibiting compounds | PFIZER INC | 2005-01-06 | — | — | US | claimed |
| US-20050004186-A1 | MEK inhibiting compounds | PFIZER INC | 2005-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004186-A1 | MEK inhibiting compounds | MAPK1, MAP3K1, MAPK3 | PIM1 74/4885CAMK2B 1041/4885FLT1 349/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.