SCHEMBL6407073

SCHEMBL6407073

COc1ccc2cc(N3c4cc(C)c(C)cc4N(c4ccc5cc(OC)ccc5c4)c4cc5ccccc5cc43)ccc2c1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.55
CYP2A6 P11509 1/20 0.55
CYP11B1 P15538 3/20 0.43
CYP11B2 P19099 3/20 0.43
HTR1A P08908 1/20 0.42
HTR1D P28221 1/20 0.42
HTR1B P28222 1/20 0.42
ACHE P22303 2/20 0.41
HSP90AA1 P07900 1/20 0.40
NPBWR1 P48145 1/20 0.40
RAB9A P51151 5/20 0.38
ALDH1A1 P00352 2/20 0.38
GAA P10253 1/20 0.38
MGLL Q99685 1/20 0.38
METAP2 P50579 1/20 0.38
SMN1; SMN2 Q16637 3/20 0.38
NPC1 O15118 3/20 0.38
LMNA P02545 2/20 0.38
CYP3A4 P08684 2/20 0.38
CYP2C9 P11712 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6404071 0.94 CYP1A2 (0.62) CYP1A2CYP2A6CYP11B1CYP11B2HTR1A
SCHEMBL6404589 0.87 HSP90AA1 (0.52) CYP1A2CYP2A6CYP11B1CYP11B2HSP90AA1
SCHEMBL19343005 0.79 CYP1A2 (0.55) CYP1A2CYP2A6CYP11B1CYP11B2HTR1A
SCHEMBL17794464 0.78 HSP90AA1 (0.50) CYP1A2CYP2A6CYP11B1CYP11B2HSP90AA1
SCHEMBL6400292 0.77 HSP90AA1 (0.61) CYP1A2CYP2A6CYP11B1CYP11B2HSP90AA1
SCHEMBL13623272 0.77 CYP2A6 (0.49) CYP1A2CYP2A6CYP11B1CYP11B2HTR1A
SCHEMBL6400284 0.76 CYP2A6 (0.43) CYP1A2CYP2A6HSP90AA1RAB9AALDH1A1
SCHEMBL13886638 0.74 HSP90AA1 (0.57) CYP1A2CYP2A6CYP11B1CYP11B2HSP90AA1
SCHEMBL6400917 0.73 PDE6D (0.43) RAB9AMGLLNPC1MEN1KMT2A
SCHEMBL112792 0.73 CYP1A2 (1.00) CYP1A2CYP2A6CYP11B1CYP11B2ACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6919140-B2 Organic electroluminescent devices with high luminance EASTMAN KODAK COMPANY (US) 2005-07-19 US disclosed
US-20050014018-A1 Organic electroluminescent devices with high luminance EASTMAN KODAK COMPANY 2005-01-20 US disclosed