SCHEMBL6404589

SCHEMBL6404589

Cc1cc2c(cc1C)N(c1ccc3ccccc3c1)c1cc3ccccc3cc1N2c1ccc2ccccc2c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 1/20 0.52
RAB9A P51151 3/20 0.47
CYP1A2 P05177 2/20 0.47
CYP2C9 P11712 2/20 0.47
CYP2C19 P33261 2/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
CYP3A4 P08684 1/20 0.47
KMT2A Q03164 2/20 0.45
POLB P06746 2/20 0.45
HTR3A P46098 2/20 0.44
ALDH1A1 P00352 4/20 0.44
GAA P10253 1/20 0.44
CYP2A6 P11509 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
MEN1 O00255 1/20 0.41
HTR3E A5X5Y0 1/20 0.41
HTR3B O95264 1/20 0.41
HTR5A P47898 1/20 0.41
HTR3D Q70Z44 1/20 0.41
HTR3C Q8WXA8 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17794464 0.91 HSP90AA1 (0.50) HSP90AA1RAB9ACYP1A2CYP2C9CYP2C19
SCHEMBL6400292 0.90 HSP90AA1 (0.61) HSP90AA1RAB9ACYP1A2CYP2C9CYP2C19
SCHEMBL6407073 0.87 CYP1A2 (0.55) HSP90AA1RAB9ACYP1A2CYP2C9CYP2C19
SCHEMBL13886638 0.86 HSP90AA1 (0.57) HSP90AA1RAB9ACYP1A2CYP2C9CYP2C19
SCHEMBL6400284 0.85 CYP2A6 (0.43) HSP90AA1RAB9ACYP1A2CYP2C9CYP2C19
SCHEMBL6400917 0.81 PDE6D (0.43) RAB9AKMT2AMEN1NPC1
SCHEMBL16281049 0.81 HSP90AA1 (0.61) HSP90AA1RAB9ACYP1A2CYP2C9CYP2C19
SCHEMBL13886639 0.81 HSP90AA1 (0.61) HSP90AA1RAB9ACYP1A2CYP2C9CYP2C19
SCHEMBL30286079 0.81 HSP90AA1 (0.61) HSP90AA1RAB9ACYP1A2CYP2C9CYP2C19
SCHEMBL19355007 0.78 RAB9A (0.45) HSP90AA1RAB9ACYP1A2CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6919140-B2 Organic electroluminescent devices with high luminance EASTMAN KODAK COMPANY (US) 2005-07-19 US disclosed
US-20050014018-A1 Organic electroluminescent devices with high luminance EASTMAN KODAK COMPANY 2005-01-20 US disclosed