Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10000246 | 0.80 | NPSR1 (0.48) | NPSR1L3MBTL1MAPTNPC1RAB9A | |
| SCHEMBL10000245 | 0.80 | NPSR1 (0.48) | NPSR1L3MBTL1MAPTNPC1RAB9A | |
| SCHEMBL1743253 | 0.80 | NPC1 (0.52) | NPSR1L3MBTL1MAPTNPC1RAB9A | |
| SCHEMBL11167793 | 0.79 | PIK3CD (0.57) | NPSR1L3MBTL1MAPTNPC1RAB9A | |
| SCHEMBL8098714 | 0.79 | NPC1 (0.35) | NPSR1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2608309 | 0.78 | NPC1 (0.60) | NPSR1L3MBTL1MAPTNPC1RAB9A | |
| SCHEMBL16161600 | 0.78 | RAB9A (0.58) | NPSR1L3MBTL1MAPTNPC1RAB9A | |
| SCHEMBL9613271 | 0.76 | LMNA (0.52) | NPSR1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL12441005 | 0.76 | NPSR1 (0.46) | NPSR1L3MBTL1MAPTNPC1RAB9A | |
| SCHEMBL27643315 | 0.76 | NPC1 (0.55) | NPSR1MAPTNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8293757-B2 | 5-(4-(haloalkoxy)phenyl) pyrimidine-2-amine compounds and compositions as kinase inhibitors | IRM LLC (BM) | 2012-10-23 | — | — | US | disclosed |
| CN-100562518-C | Arylethene-sulfonamides compounds | ACTELION PHARMACEUTICALS LTD (CH) | 2009-11-25 | — | — | CN | disclosed |
| CN-100537546-C | Novel alkansulfonamides as endothelin antagonists | ACTELION PHARMACEUTICALS LTD (CH) | 2009-09-09 | — | — | CN | disclosed |
| CN-100432070-C | Novel sulfamides and their use as endothelin receptor antagonists | ACTELION PHARMACEUTICALS LTD (CH) | 2008-11-12 | — | — | CN | disclosed |
| CN-1326841-C | Arylalkane-sulfonamides having endothelin antagonist activity | ACTELION PHARMACEUTICALS LTD (CH) | 2007-07-18 | — | — | CN | disclosed |
| CN-1633418-A | Arylalkane-sulfonamides having endothelin-antagonist activity | ACTELION PHARMACEUTICALS LTD (CH) | 2005-06-29 | — | — | CN | disclosed |
| US-20050113402-A1 | Substituted pyrrolopyridinone derivatives useful as phosphodiesterase inhibitors | SUI ZHIHUA (US) | 2005-05-26 | — | — | US | disclosed |
| CN-1612864-A | Novel alkansulfonamides as endothelin antagonists | ACTELION PHARMACEUTICALS LTD (CH) | 2005-05-04 | — | — | CN | disclosed |
| US-6818646-B2 | 1,2,3,4-TETRAHYDRO-2-(5-(2-PYRIDINYL)-PYRIMIDIN-2-YL)-3-(2,3 -DIHYDROBENZOFURANYL)-9H-PYRROLO-(3,4-B)QUINOLIN-9-ONE; MALE ERECTILE DYSFUNCTION; SEXUAL DISORDERS | SUI ZHIHUA (US) | 2004-11-16 | — | — | US | disclosed |
| EP-1296981-B1 | SUBSTITUTED PYRROLOPYRIDINONE DERIVATIVES USEFUL AS PHOSPHODIESTERASE INHIBITORS | ORTHO MCNEIL PHARM INC (US) | 2004-10-06 | — | — | EP | disclosed |
| CN-1524079-A | Novel sulfonamides and their use as endothelin receptor antagonists | ������˹ҩƷ��˾ | 2004-08-25 | — | — | CN | disclosed |
| US-20040044021-A1 | Substituted pyrrolopyridinone derivatives useful as phosphodiesterase inhibitors | SUI ZHIHUA (US) | 2004-03-04 | — | — | US | disclosed |
| US-6635638-B2 | Treatment of sexual dysfunction, cardiovascular system disorders | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2003-10-21 | — | — | US | disclosed |
| CN-1441788-A | Novel arylethene sulfonamides | ACTELION PHARMACEUTICALS LTD (CH) | 2003-09-10 | — | — | CN | disclosed |
| EP-1296981-A2 | SUBSTITUTED PYRROLOPYRIDINONE DERIVATIVES USEFUL AS PHOSPHODIESTERASE INHIBITORS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-04-02 | — | — | EP | disclosed |
| CN-1100043-C | Sulfonamide derivative and process for producing the same | TANABE SEIYAKU CO (JP) | 2003-01-29 | — | — | CN | disclosed |
| US-20020010183-A1 | Substituted pyrrolopyridinone derivatives useful as phosphodiesterase inhibitors | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2002-01-24 | — | — | US | disclosed |
| WO-2001087882-A2 | SUBSTITUTED PYRROLOPYRIDINONE DERIVATIVES USEFUL AS PHOSPHODIESTERASE INHIBITORS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2001-11-22 | — | — | WO | disclosed |
| CN-1146990-A | Sulfonamide derivative and process for preparing the same | TANABE SEIYAKU CO (JP) | 1997-04-09 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050113402-A1 | Substituted pyrrolopyridinone derivatives useful as phosphodiesterase inhibitors | PDE5A, PDE3A, PDE3B | NPSR1 984/4885L3MBTL1 4867/4885MAPT 3888/4885 |
| US-20040044021-A1 | Substituted pyrrolopyridinone derivatives useful as phosphodiesterase inhibitors | PDE5A, PDE3A, PDE3B | NPSR1 793/4885L3MBTL1 4866/4885MAPT 3924/4885 |
| US-20020010183-A1 | Substituted pyrrolopyridinone derivatives useful as phosphodiesterase inhibitors | PDE5A, PDE3A, PDE3B | NPSR1 793/4885L3MBTL1 4866/4885MAPT 3924/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.