Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC1 | P07992 | 1/20 | 0.62 |
| ▸ | FEN1 | P39748 | 1/20 | 0.62 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.62 |
| ▸ | PGR | P06401 | 1/20 | 0.59 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.51 |
| ▸ | GPR3 | P46089 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | GALK1 | P51570 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.47 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | NQO2 | P16083 | 1/20 | 0.46 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6366340 | 0.82 | ERCC1 (0.69) | ERCC1FEN1ERCC4PGRNPEPPS | |
| SCHEMBL30665027 | 0.82 | ERCC1 (0.69) | ERCC1FEN1ERCC4PGRNPEPPS | |
| SCHEMBL5143886 | 0.79 | CYP1A2 (0.47) | ERCC1FEN1ERCC4PGRGPR3 | |
| SCHEMBL6400912 | 0.78 | PGR (0.64) | PGRHSD17B10KMT2AGAACASP1 | |
| SCHEMBL17242776 | 0.77 | ERCC1 (0.62) | ERCC1FEN1ERCC4PGRNPEPPS | |
| SCHEMBL19577294 | 0.77 | PGR (0.64) | ERCC1FEN1ERCC4PGRNPEPPS | |
| SCHEMBL11394064 | 0.76 | ERCC1 (0.61) | ERCC1FEN1ERCC4PGRNPEPPS | |
| SCHEMBL16352662 | 0.76 | ERCC1 (0.61) | ERCC1FEN1ERCC4PGRNPEPPS | |
| SCHEMBL14692425 | 0.75 | ERCC1 (0.56) | ERCC1FEN1ERCC4PGRNPEPPS | |
| SCHEMBL6360759 | 0.74 | PGR (1.00) | ERCC1FEN1ERCC4PGRNPEPPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050054696-A1 | Indole compounds and medicinal use thereof | JAPAN TOBACCO INC. (JP) | 2005-03-10 | — | — | US | claimed |
| EP-1452526-A1 | INDOLE COMPOUND AND MEDICINAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2004-09-01 | — | — | EP | claimed |
| US-20050054696-A1 | Indole compounds and medicinal use thereof | JAPAN TOBACCO INC. (JP) | 2005-03-10 | — | — | US | disclosed |
| EP-1452526-A1 | INDOLE COMPOUND AND MEDICINAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2004-09-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054696-A1 | Indole compounds and medicinal use thereof | IDO1, GPR119, SLC5A1 | ERCC1 4830/4885FEN1 4681/4885ERCC4 4852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.