Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.55 |
| ▸ | RAB9A | P51151 | 6/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.53 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6408618 | 0.94 | SMN1; SMN2 (0.62) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL6402547 | 0.90 | SMN1; SMN2 (0.57) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL6407778 | 0.90 | HSD17B10 (0.62) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL6405915 | 0.89 | NPC1 (0.64) | NPC1RAB9ASMN1; SMN2KCNK9KMT2A | |
| SCHEMBL6404235 | 0.89 | SMN1; SMN2 (0.56) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL6402278 | 0.88 | HDAC6 (0.57) | NPC1RAB9ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL6410111 | 0.88 | SMN1; SMN2 (0.62) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL6410519 | 0.87 | NPC1 (0.59) | NPC1RAB9ASMN1; SMN2MAPTHSD17B10 | |
| SCHEMBL6405888 | 0.86 | SMN1; SMN2 (0.53) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL6402541 | 0.86 | RXFP1 (0.65) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101528737-B | Novel heteroaryl carboxamides | HOFFMANN LA ROCHE | 2012-07-04 | — | — | CN | disclosed |
| US-20050171358-A1 | Substituted isoxazole alkylamine derivative and agri-and horticultural fungicide | SDS BIOTECH K.K. (JP) | 2005-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050171358-A1 | Substituted isoxazole alkylamine derivative and agri-and horticultural fungicide | AHR, ERG28, CYP1A2 | NPC1 1915/4885RAB9A 4044/4885SMN1; SMN2 4458/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.