Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 3/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | PRCP | P42785 | 2/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | RGS12 | O14924 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8805271 | 0.77 | PRCP (0.40) | ADRA1AADRA2ADRD1PRCPTRPM8 | |
| SCHEMBL2600445 | 0.72 | PRCP (0.47) | DRD1PRCPTRPM8CHRNA7 | |
| SCHEMBL25163043 | 0.72 | PRCP (0.47) | DRD1PRCPTRPM8CHRNA7 | |
| SCHEMBL23112103 | 0.72 | AKR1C3 (0.39) | ADRA1AADRA2ADRD1PRCPTRPM8 | |
| SCHEMBL23112118 | 0.70 | ROCK1 (0.37) | ADRA1AADRA2ADRD1PRCPTRPM8 | |
| SCHEMBL6994246 | 0.70 | DRD1 (0.40) | DRD1PRCPTRPM8KDM4EGRM5 | |
| SCHEMBL5319075 | 0.69 | ROCK1 (0.50) | ADRA1AMAPTMEN1KMT2A | |
| SCHEMBL8803439 | 0.69 | DRD1 (0.39) | ADRA1AADRA1DADRA1BDRD1PRCP | |
| SCHEMBL1735608 | 0.68 | MAPT (0.37) | ADRA1AADRA2AADRA1DADRA1BDRD1 | |
| SCHEMBL28848016 | 0.68 | ALDH1A1 (0.45) | DRD1PRCPTRPM8MAPTCHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6849644-B2 | Isoquinoline derivatives useful in the treatment of CNS disorders | SMITHKLINE BEECHAM P.L.C. (GB) | 2005-02-01 | — | — | US | disclosed |
| US-20040053956-A1 | Isoquinoline derivatives useful in the treatment of cns disorders | SMITHKLINE BEECHAM P.L.C. (GB) | 2004-03-18 | — | — | US | disclosed |
| EP-1341783-A1 | ISOQUINOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CNS DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 2003-09-10 | — | — | EP | disclosed |
| WO-2002042293-A1 | ISOQUINOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CNS DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-05-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040053956-A1 | Isoquinoline derivatives useful in the treatment of cns disorders | INA, NLN, GRIN2C | ADRA1A 640/4885ADRA2A 356/4885ADRA1D 732/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.