Sugi Predict

Sugi Predict / Compounds / SCHEMBL6408670

SCHEMBL6408670

SCHEMBL6408670

N=C(N)c1ccc(OCCCCOc2ccc(C(=N)N)cc2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PRSS1 P07477 8/20 1.00
▸ PRMT1 Q99873 3/20 0.96
▸ F2 P00734 2/20 0.96
▸ ST14 Q9Y5Y6 2/20 0.96
▸ TMPRSS2 O15393 2/20 0.96
▸ PLAU P00749 1/20 0.96
▸ PRMT5 O14744 1/20 0.96
▸ SLC22A2 O15244 1/20 0.96
▸ SLC22A1 O15245 1/20 0.96
▸ PTP4A3 O75365 1/20 0.96
▸ SLC22A3 O75751 1/20 0.96
▸ F10 P00742 1/20 0.96
▸ PLG P00747 1/20 0.96
▸ S100B P04271 1/20 0.96
▸ CHRM2 P08172 1/20 0.96
▸ CHRM4 P08173 1/20 0.96
▸ CHRM5 P08912 1/20 0.96
▸ ADRA2A P08913 1/20 0.96
▸ CYP2D6 P10635 1/20 0.96
▸ AOC1 P19801 1/20 0.96

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14599631 0.98 PRMT1 (1.00) PRSS1PRMT1F2ST14TMPRSS2
Pentamidine SCHEMBL3329 0.98 PRMT1 (1.00) PRSS1PRMT1F2ST14TMPRSS2
SCHEMBL14599628 0.98 PRMT1 (1.00) PRSS1PRMT1F2ST14TMPRSS2
Hexamidine SCHEMBL144738 0.98 PRMT1 (1.00) PRSS1PRMT1F2ST14TMPRSS2
SCHEMBL14599639 0.98 PRMT1 (1.00) PRSS1PRMT1F2ST14TMPRSS2
Heptamidine SCHEMBL14599630 0.98 PRMT1 (1.00) PRSS1PRMT1F2ST14TMPRSS2
Pentamidine SCHEMBL7060561 0.96 PRSS1 (1.00) PRSS1PRMT1F2ST14TMPRSS2
Pentamidine SCHEMBL3227 0.96 PRSS1 (1.00) PRSS1PRMT1F2ST14TMPRSS2
Pentamidine SCHEMBL6906034 0.96 PRMT1 (0.96) PRSS1PRMT1F2ST14TMPRSS2
Hexamidine SCHEMBL306398 0.96 PRMT1 (0.96) PRSS1PRMT1F2ST14TMPRSS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018130840-A1 ARGININE METHYLATION INHIBITOR FOR TREATING OR PREVENTING CARDIOVASCULAR DISEASE THE UNIVERSITY OF HULL (GB) 2018-07-19 — — WO claimed
CN-116669548-A Low drift, rain wash resistant, high absorption and ULV tank mix adjuvant formulations 拜耳公司 2023-08-29 — — CN disclosed
CN-113057169-B Herbicidal composition containing bicyclopyrone and application thereof 青岛清原化合物有限公司 2022-07-01 — — CN disclosed
CN-111031797-B Herbicidal compositions comprising 4-amino-3-chloro-5-fluoro-6- (4-chloro-2-fluoro-3-methoxyphenyl) pyridine-2-carboxylic acid or a derivative thereof and tembotrione and/or topramezone 美国陶氏益农公司 2022-06-21 — — CN disclosed
CN-114521562-A Ternary weeding composition and application thereof 青岛清原化合物有限公司 2022-05-24 — — CN disclosed
CN-114451412-A Use of acyclic picolinamides as fungicides for controlling phytopathogenic fungi 美国陶氏益农公司 2022-05-10 — — CN disclosed
CN-114451413-A Use of acyclic picolinamides as fungicides for controlling phytopathogenic fungi in vegetables 美国陶氏益农公司 2022-05-10 — — CN disclosed
CN-114431244-A Ternary herbicidal composition containing HPPD inhibitor herbicide and application thereof 青岛清原化合物有限公司 2022-05-06 — — CN disclosed
CN-114431236-A Ternary herbicidal compositions comprising carboxylic acid derivative-substituted oxyiminoaryl compounds and their use 青岛清原化合物有限公司 2022-05-06 — — CN disclosed
CN-113142217-B Ternary herbicidal composition containing HPPD inhibitor herbicide and application thereof 青岛清原化合物有限公司 2022-04-22 — — CN disclosed
US-20070021483-A1 Amidine derivatives for treating amyloidosis NEUROCHEM (INTERNATIONAL) LIMITED (CH) 2007-01-25 — — US disclosed
EP-1561463-A2 Benzamidoxime prodrugs as antipneumocystic agents THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2005-08-10 — — EP disclosed
EP-0861071-B1 BENZAMIDOXIME PRODRUGS AND USE THEREOF FOR TREATING PNEUMONIA UNIV NORTH CAROLINA (US) 2005-05-11 — — EP disclosed
US-6423737-B2 Benzamidoxime prodrugs as antipneumocystic agents THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL 2002-07-23 — — US disclosed
US-6214883-B1 BIS//N-HYDROXYAMIDINO/PHENOXY OR -THIO/ALKANES REDUCED AFTER ORAL ADMINISTRATION TO THE CORRESPONDING MONO- OR BISAMIDINES THE GEORGIA STATE UNIVERSITY 2001-04-10 — — US disclosed
EP-0861071-A1 BENZAMIDOXIME PRODRUGS AS ANTIPNEUMOCYSTIC AGENTS THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 1998-09-02 — — EP disclosed
WO-1997017949-A1 BENZAMIDOXIME PRODRUGS AS ANTIPNEUMOCYSTIC AGENTS THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 1997-05-22 — — WO disclosed
US-5462969-A Administering a mixture of an iron chelator and pentamide NEW YORK UNIVERSITY (US) 1995-10-31 — — US disclosed
US-5302598-A Administering an iron chelator and trimethoprim/sulfamethoxazole to treat and prevent AIDS-related pneumonia NEW YORK UNIVERSITY (US) 1994-04-12 — — US disclosed
US-5158979-A Administering iron chelator NEW YORK UNIVERSITY (US) 1992-10-27 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070021483-A1 Amidine derivatives for treating amyloidosis APP, IAPP, GRN PRSS1 2062/4885PRMT1 194/4885F2 3712/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.