Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 6/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.39 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.38 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.37 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6409962 | 0.87 | ROCK2 (0.46) | CCR5ROCK2ROCK1KDM4EGPR88 | |
| Hydrochloric Acid SCHEMBL6415642 | 0.86 | CCR5 (0.46) | CCR5ALDH1A1ROCK2ROCK1 | |
| SCHEMBL6409016 | 0.84 | HCRTR2 (0.43) | CCR5HCRTR2ALDH1A1ROCK2ROCK1 | |
| SCHEMBL6409501 | 0.84 | HCRTR2 (0.43) | CCR5HCRTR2ALDH1A1ROCK2ROCK1 | |
| Hydrochloric Acid SCHEMBL6410988 | 0.84 | HCRTR2 (0.42) | CCR5HCRTR2ALDH1A1ROCK2ROCK1 | |
| SCHEMBL6409300 | 0.83 | CCR5 (0.44) | CCR5ROCK2ROCK1LMNA | |
| SCHEMBL6409295 | 0.83 | CCR5 (0.44) | CCR5ROCK2ROCK1LMNA | |
| Hydrochloric Acid SCHEMBL6410911 | 0.83 | UTS2R (0.46) | CCR5 | |
| SCHEMBL6412938 | 0.83 | EGLN1 (0.52) | EGLN1HCRTR2ALDH1A1KDM4ELMNA | |
| SCHEMBL6414757 | 0.82 | CCR5 (0.45) | CCR5ALDH1A1ROCK2ROCK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050075326-A1 | Spiro compounds and methods for the modulation of chemokine receptor activity | VIROCHEM PHARMA INC (CA) | 2005-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050075326-A1 | Spiro compounds and methods for the modulation of chemokine receptor activity | CXCR1, CXCR4, CXCR2 | CCR5 4/4885EGLN1 2490/4885HCRTR2 247/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.