Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 6/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6409569 | 0.99 | MAPT (0.51) | MAPTROCK2ROCK1POLBALDH1A1 | |
| SCHEMBL6409263 | 0.94 | ROCK2 (0.49) | MAPTROCK2ROCK1POLBALDH1A1 | |
| SCHEMBL6414577 | 0.93 | POLB (0.48) | MAPTROCK2ROCK1POLBALDH1A1 | |
| Hydrochloric Acid SCHEMBL6409256 | 0.93 | ROCK2 (0.48) | MAPTROCK2ROCK1POLBALDH1A1 | |
| Hydrochloric Acid SCHEMBL6414565 | 0.93 | POLB (0.47) | MAPTROCK2ROCK1POLBALDH1A1 | |
| SCHEMBL6412131 | 0.92 | MAPT (0.44) | MAPTROCK2ROCK1POLBALDH1A1 | |
| SCHEMBL6417321 | 0.91 | ALDH1A1 (0.48) | MAPTROCK2ROCK1POLBALDH1A1 | |
| Hydrochloric Acid SCHEMBL5252466 | 0.91 | MAPT (0.43) | MAPTROCK2ROCK1POLBALDH1A1 | |
| Hydrochloric Acid SCHEMBL6417316 | 0.91 | ALDH1A1 (0.47) | MAPTROCK2ROCK1POLBALDH1A1 | |
| Hydrochloric Acid SCHEMBL6417381 | 0.90 | ROCK2 (0.47) | MAPTROCK2ROCK1POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050075326-A1 | Spiro compounds and methods for the modulation of chemokine receptor activity | VIROCHEM PHARMA INC (CA) | 2005-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050075326-A1 | Spiro compounds and methods for the modulation of chemokine receptor activity | CXCR1, CXCR4, CXCR2 | MAPT 4525/4885ROCK2 1735/4885ROCK1 1002/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.