Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | CCR3 | P51677 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | CXCR3 | P49682 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6409172 | 0.99 | HSD11B1 (0.42) | HSD11B1CCR3CCR5CXCR3LMNA | |
| SCHEMBL6412023 | 0.89 | CCR5 (0.42) | HSD11B1CCR5LMNANPSR1HDAC11 | |
| SCHEMBL5252363 | 0.89 | CCR5 (0.42) | HSD11B1CCR5LMNANPSR1HDAC11 | |
| Hydrochloric Acid SCHEMBL6409551 | 0.88 | CCR5 (0.42) | HSD11B1CCR5LMNANPSR1HDAC11 | |
| Hydrochloric Acid SCHEMBL6409549 | 0.88 | CCR5 (0.42) | HSD11B1CCR5LMNANPSR1HDAC11 | |
| SCHEMBL6409656 | 0.87 | CCR5 (0.47) | HSD11B1CCR3CCR5CXCR3LMNA | |
| SCHEMBL6409295 | 0.87 | CCR5 (0.44) | HSD11B1CCR5CXCR3LMNANPSR1 | |
| SCHEMBL6409300 | 0.87 | CCR5 (0.44) | HSD11B1CCR5CXCR3LMNANPSR1 | |
| SCHEMBL6415563 | 0.87 | HSD11B1 (0.45) | HSD11B1CCR3CCR5CXCR3LMNA | |
| Hydrochloric Acid SCHEMBL6415467 | 0.86 | CCR5 (0.46) | HSD11B1CCR3CCR5CXCR3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050075326-A1 | Spiro compounds and methods for the modulation of chemokine receptor activity | VIROCHEM PHARMA INC (CA) | 2005-04-07 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050075326-A1 | Spiro compounds and methods for the modulation of chemokine receptor activity | CXCR1, CXCR4, CXCR2 | HSD11B1 120/4885CCR3 13/4885CCR5 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.