Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | MPI | P34949 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30718037 | 0.90 | ALDH1A1 (0.54) | HTTKDM4EKDRPDE3BPDE3A | |
| SCHEMBL643543 | 0.90 | ALDH1A1 (0.54) | HTTKDM4EKDRPDE3BPDE3A | |
| SCHEMBL4792028 | 0.81 | METAP1 (0.43) | HTTKDM4EKDRPARP1CDK1 | |
| SCHEMBL15756851 | 0.80 | PDE3B (0.54) | HTTKDM4EKDRCDK1PDE3B | |
| SCHEMBL5758982 | 0.78 | PDE3B (0.58) | HTTKDM4EPDE3BPDE3AALDH1A1 | |
| SCHEMBL30471897 | 0.77 | HRH3 (0.52) | KDRPARP1CDK1MAPKAPK2PDE3B | |
| SCHEMBL1395133 | 0.77 | HRH3 (0.52) | KDRPARP1CDK1MAPKAPK2PDE3B | |
| SCHEMBL23766349 | 0.76 | PDE3B (0.47) | HTTKDM4EKDRCDK1PDE3B | |
| SCHEMBL2254756 | 0.76 | PDE3B (0.56) | HTTKDM4EKDRCDK1PDE3B | |
| SCHEMBL29783338 | 0.76 | PDE3B (0.56) | HTTKDM4EKDRCDK1PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11850287-B2 | Heterocyclic acyl hydrazone linkers, methods and uses thereof | ONTARIO INSTITUTE FOR CANCER SEARCH (OICR) (CA) | 2023-12-26 | — | — | US | disclosed |
| US-20210106694-A1 | HETEROCYCLIC ACYL HYDRAZONE LINKERS, METHODS AND USES THEREOF | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2021-04-15 | — | — | US | disclosed |
| US-20210106694-A1 | HETEROCYCLIC ACYL HYDRAZONE LINKERS, METHODS AND USES THEREOF | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2021-04-15 | — | — | US | disclosed |
| EP-3728273-A1 | HETEROCYCLIC ACYL HYDRAZONE LINKERS, METHODS AND USES THEREOF | Ontario Institute for Cancer Research (OICR) (CA) | 2020-10-28 | — | — | EP | disclosed |
| US-20050234041-A1 | Substituted 1-benzazepines and derivatives thereof | BIOPORT R&D, INC. | 2005-10-20 | — | — | US | disclosed |
| US-6514965-B1 | For treating bacterial infections | ANTEX PHARMA INC. | 2003-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210106694-A1 | HETEROCYCLIC ACYL HYDRAZONE LINKERS, METHODS AND USES THEREOF | HDAC6, C9, AADAC | HTT 1365/4885KDM4E 1071/4885KDR 2720/4885 |
| US-20050234041-A1 | Substituted 1-benzazepines and derivatives thereof | BAK1, BAD, BAX | HTT 3237/4885KDM4E 278/4885KDR 3033/4885 |
| US-11850287-B2 | Heterocyclic acyl hydrazone linkers, methods and uses thereof | HDAC6, C9, AADAC | HTT 1365/4885KDM4E 1071/4885KDR 2720/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.