Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.58 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | CASP1 | P29466 | 1/20 | 0.54 |
| ▸ | MPI | P34949 | 1/20 | 0.54 |
| ▸ | CASP7 | P55210 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30718037 | 0.87 | ALDH1A1 (0.54) | PDE3BPDE3AALDH1A1HPGDMEN1 | |
| SCHEMBL643543 | 0.87 | ALDH1A1 (0.54) | PDE3BPDE3AALDH1A1HPGDMEN1 | |
| SCHEMBL29199414 | 0.83 | PDE3B (0.61) | PDE3BPDE3AALDH1A1HPGDHTT | |
| SCHEMBL22451527 | 0.82 | RYR2 (0.56) | PDE3BPDE3AALDH1A1HPGDMEN1 | |
| SCHEMBL29115795 | 0.81 | ALDH1A1 (0.41) | PDE3BPDE3AALDH1A1HPGDMEN1 | |
| SCHEMBL6754939 | 0.80 | CES1 (0.54) | PDE3BPDE3AALDH1A1HPGDMEN1 | |
| SCHEMBL1183750 | 0.79 | PDE3B (0.74) | PDE3BPDE3AALDH1A1HPGDHTT | |
| SCHEMBL6409810 | 0.78 | HTT (0.48) | PDE3BPDE3AALDH1A1HPGDMEN1 | |
| SCHEMBL5546719 | 0.77 | ALDH1A1 (0.58) | ALDH1A1HPGDMEN1KMT2AHTT | |
| SCHEMBL16963878 | 0.76 | PDE3B (0.61) | PDE3BPDE3AALDH1A1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117069658-A | Preparation method of 4-oxo-6-methoxy-3- (2, 3-dichlorophenyl) methyl-1 (4H) -quinolineacetic acid | 宁夏康亚药业股份有限公司 | 2023-11-17 | — | — | CN | claimed |
| CN-117069658-A | Preparation method of 4-oxo-6-methoxy-3- (2, 3-dichlorophenyl) methyl-1 (4H) -quinolineacetic acid | 宁夏康亚药业股份有限公司 | 2023-11-17 | — | — | CN | disclosed |
| CN-117069658-A | Preparation method of 4-oxo-6-methoxy-3- (2, 3-dichlorophenyl) methyl-1 (4H) -quinolineacetic acid | 宁夏康亚药业股份有限公司 | 2023-11-17 | — | — | CN | disclosed |
| CN-113372268-B | 4-oxo-6-methoxy-3- (2, 3-dichlorophenyl) methyl-1 (4H) quinolineacetic acid metabolites | 宁夏康亚药业股份有限公司 | 2023-10-17 | — | — | CN | disclosed |
| CN-113372268-A | 4-oxo-6-methoxy-3- (2, 3-dichlorophenyl) methyl-1 (4H) quinolineacetic acid metabolites | 宁夏康亚药业股份有限公司 | 2021-09-10 | — | — | CN | disclosed |
| CN-103772276-A | Preparation method of 2-(6-methoxy-3-(2, 3-dichlorophenyl) methyl-4-oxo-1, 4-dihydro-1(4H)-quinolyl) acetic acid | UNIV SHENYANG PHARMACEUTICAL | 2014-05-07 | — | — | CN | disclosed |
| CN-103739547-A | Synthesis method of 2-[6-methoxy-3-(2,3-dichlorophenyl)methyl-4-oxo-1,4-dihydro-1(4H)-quinolyl] acetic acid | UNIV SHENYANG PHARMACEUTICAL | 2014-04-23 | — | — | CN | disclosed |
| US-7101869-B2 | 2,4-diaminopyrimidine compounds useful as immunosuppressants | PFIZER INC. (US) | 2006-09-05 | — | — | US | disclosed |
| EP-1242403-B1 | 2,4-DIAMINOPYRIMIDINE COMPOUNDS USFUL AS IMMUNOSUPPRESSANTS | PFIZER PROD INC (US) | 2006-01-04 | — | — | EP | disclosed |
| US-20030191307-A1 | 2,4-Diaminopyrimidine compounds useful as immunosuppressants | BLUMENKOPF TODD A (US) | 2003-10-09 | — | — | US | disclosed |
| EP-1242403-A1 | 2,4-DIAMINOPYRIMIDINE COMPOUNDS USFUL AS IMMUNOSUPPRESSANTS | Pfizer Products Inc. (US) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001040215-A1 | 2,4-DIAMINOPYRIMIDINE COMPOUNDS USFUL AS IMMUNOSUPPRESSANTS | PFIZER PRODUCTS INC. (US) | 2001-06-07 | — | — | WO | disclosed |
| US-4585867-A | Process for the preparation of 4-quinolinones | RHONE-POULENC SANTE (FR) | 1986-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030191307-A1 | 2,4-Diaminopyrimidine compounds useful as immunosuppressants | CCR1, AOC1, NOD1 | PDE3B 2269/4885PDE3A 2215/4885ALDH1A1 495/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.