SCHEMBL6409908

SCHEMBL6409908

O=C(CBr)CC(=O)Nc1cccc(Cl)c1

nearest known ligand 0.64

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 6/20 0.59
KMT2A Q03164 6/20 0.59
MAPT P10636 6/20 0.59
ALDH1A1 P00352 4/20 0.59
LMNA P02545 3/20 0.59
HTT P42858 2/20 0.59
HSD17B10 Q99714 1/20 0.56
KCNJ5 P48544 1/20 0.56
KCNJ3 P48549 1/20 0.56
MAOA P21397 1/20 0.56
MAOB P27338 1/20 0.56
RAB9A P51151 3/20 0.54
NPC1 O15118 2/20 0.54
EPHX2 P34913 1/20 0.54
HPGD P15428 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31590348 1.00 MEN1 (0.59) MEN1KMT2AMAPTALDH1A1LMNA
SCHEMBL333559 0.88 MEN1 (0.65) MEN1KMT2AMAPTALDH1A1LMNA
SCHEMBL29748804 0.88 MEN1 (0.65) MEN1KMT2AMAPTALDH1A1LMNA
SCHEMBL5141417 0.86 MEN1 (0.71) MEN1KMT2AMAPTALDH1A1LMNA
SCHEMBL1503951 0.81 MEN1 (0.65) MEN1KMT2AMAPTALDH1A1LMNA
SCHEMBL9428788 0.80 MAPT (0.62) MEN1KMT2AMAPTALDH1A1LMNA
SCHEMBL18530322 0.80 MEN1 (0.68) MEN1KMT2AMAPTALDH1A1LMNA
SCHEMBL6407780 0.80 KMT2A (0.56) MEN1KMT2AMAPTALDH1A1LMNA
SCHEMBL7646371 0.80 MEN1 (0.67) MEN1KMT2AMAPTALDH1A1LMNA
SCHEMBL30475544 0.80 MEN1 (0.67) MEN1KMT2AMAPTALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6921770-B2 2-Phenyliminothiazolines, their preparation method and anti-rice blast agent containing the same KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2005-07-26 US disclosed
EP-1311160-A4 2-PHENYLIMINOTHIAZOLINES, THEIR PREPARATION METHOD AND ANTI-RICE BLAST AGENT CONTAINING THE SAME KOREA INST SCI & TECH (KR) 2004-04-21 EP disclosed
US-20030203950-A1 2-Phenyliminothiazolines, their preparation method and anti-rice blast agent containing the same KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2003-10-30 US disclosed
EP-1311160-A1 2-PHENYLIMINOTHIAZOLINES, THEIR PREPARATION METHOD AND ANTI-RICE BLAST AGENT CONTAINING THE SAME KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2003-05-21 EP disclosed
WO-2002013611-A1 2-PHENYLIMINOTHIAZOLINES, THEIR PREPARATION METHOD AND ANTI-RICE BLAST AGENT CONTAINING THE SAME KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2002-02-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030203950-A1 2-Phenyliminothiazolines, their preparation method and anti-rice blast agent containing the same TYR, SYPL1, SSBP1 MEN1 131/4885KMT2A 2739/4885MAPT 1315/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.