SCHEMBL6409978

SCHEMBL6409978

Cc1ccc(NC(=O)CC(=O)CCl)cc1Cl

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 3/20 0.64
ALDH1A1 P00352 7/20 0.61
KMT2A Q03164 4/20 0.59
MEN1 O00255 3/20 0.59
MAPT P10636 3/20 0.59
MAPK1 P28482 2/20 0.59
LMNA P02545 2/20 0.59
TSHR P16473 1/20 0.59
ALOX15 P16050 1/20 0.59
POLB P06746 3/20 0.57
RAB9A P51151 2/20 0.56
RECQL P46063 1/20 0.56
CYP3A4 P08684 2/20 0.54
CYP1A2 P05177 1/20 0.54
CYP2C9 P11712 1/20 0.54
CYP2C19 P33261 1/20 0.54
GLA P06280 1/20 0.54
NPC1 O15118 2/20 0.54
SMN1; SMN2 Q16637 1/20 0.54
EPHX2 P34913 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4006392 0.89 HPGD (0.69) HPGDALDH1A1KMT2AMEN1MAPT
SCHEMBL11741540 0.85 CYP3A4 (0.65) ALDH1A1KMT2AMEN1MAPTLMNA
SCHEMBL10039554 0.84 HPGD (0.68) HPGDALDH1A1KMT2AMEN1MAPT
SCHEMBL12531500 0.84 HPGD (0.68) HPGDALDH1A1KMT2AMEN1MAPT
SCHEMBL3281841 0.83 HPGD (0.66) HPGDALDH1A1KMT2AMEN1MAPT
SCHEMBL12796807 0.82 CYP3A4 (0.75) HPGDALDH1A1KMT2AMEN1MAPT
SCHEMBL19153394 0.81 HPGD (0.68) HPGDALDH1A1KMT2AMEN1MAPT
SCHEMBL14886138 0.79 ALDH1A1 (0.70) HPGDALDH1A1KMT2AMEN1MAPT
SCHEMBL10617946 0.79 NPC1 (0.57) ALDH1A1KMT2AMEN1MAPTLMNA
SCHEMBL10039553 0.79 HPGD (0.70) HPGDALDH1A1KMT2AMEN1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6921770-B2 2-Phenyliminothiazolines, their preparation method and anti-rice blast agent containing the same KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2005-07-26 US disclosed
EP-1311160-A4 2-PHENYLIMINOTHIAZOLINES, THEIR PREPARATION METHOD AND ANTI-RICE BLAST AGENT CONTAINING THE SAME KOREA INST SCI & TECH (KR) 2004-04-21 EP disclosed
US-20030203950-A1 2-Phenyliminothiazolines, their preparation method and anti-rice blast agent containing the same KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2003-10-30 US disclosed
EP-1311160-A1 2-PHENYLIMINOTHIAZOLINES, THEIR PREPARATION METHOD AND ANTI-RICE BLAST AGENT CONTAINING THE SAME KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2003-05-21 EP disclosed
WO-2002013611-A1 2-PHENYLIMINOTHIAZOLINES, THEIR PREPARATION METHOD AND ANTI-RICE BLAST AGENT CONTAINING THE SAME KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2002-02-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030203950-A1 2-Phenyliminothiazolines, their preparation method and anti-rice blast agent containing the same TYR, SYPL1, SSBP1 HPGD 4696/4885ALDH1A1 4656/4885KMT2A 2739/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.