Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | AURKA | O14965 | 10/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 10/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6411043 | 0.92 | SMN1; SMN2 (0.41) | LMNATP53SMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL2401308 | 0.86 | HPGD (0.41) | POLBLMNATP53SMN1; SMN2HPGD | |
| SCHEMBL6431092 | 0.85 | AVPR1A (0.41) | POLBLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL6416282 | 0.85 | HTR1A (0.43) | — | |
| SCHEMBL6411592 | 0.84 | POLB (0.41) | POLBLMNAHPGDALDH1A1 | |
| SCHEMBL6409627 | 0.82 | HPGD (0.40) | AURKAAURKBHPGDALDH1A1 | |
| SCHEMBL6410191 | 0.82 | POLB (0.53) | POLBALDH1A1 | |
| SCHEMBL6410959 | 0.82 | GAA (0.36) | POLBLMNATP53SMN1; SMN2HPGD | |
| SCHEMBL6415977 | 0.81 | ABL1 (0.41) | POLBLMNASMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL6409948 | 0.79 | KDM4E (0.47) | POLBLMNATP53SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401841-B1 | SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO 4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN | GRUENENTHAL GMBH (DE) | 2005-08-24 | — | — | EP | claimed |
| EP-1401841-A1 | SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO 4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN | Grünenthal GmbH (DE) | 2004-03-31 | — | — | EP | claimed |
| WO-2003000699-A1 | SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO[4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN | Grünenthal GmbH (DE) | 2003-01-03 | — | — | WO | claimed |
| EP-1401841-B1 | SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO 4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN | GRUENENTHAL GMBH (DE) | 2005-08-24 | — | — | EP | disclosed |