Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 9/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 9/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6411430 | 0.89 | RAB9A (0.47) | HPGDMGLLALDH1A1HSD11B1RAB9A | |
| SCHEMBL6409626 | 0.85 | HPGD (0.41) | HPGDUSP2AURKAAURKBP2RX7 | |
| SCHEMBL6410177 | 0.82 | POLB (0.38) | HPGDAURKAAURKBALDH1A1 | |
| SCHEMBL6415785 | 0.79 | HTR1A (0.46) | — | |
| SCHEMBL6416570 | 0.79 | PKM (0.47) | MGLLALDH1A1HSD11B1EPHX2 | |
| SCHEMBL6416363 | 0.79 | KDM4E (0.46) | NPC1 | |
| SCHEMBL6409565 | 0.79 | GAA (0.41) | AURKAAURKBP2RX7NPC1RAB9A | |
| SCHEMBL6415762 | 0.77 | KMT2A (0.64) | ALDH1A1 | |
| SCHEMBL2400039 | 0.77 | HPGD (0.44) | HPGDUSP2AURKAAURKBP2RX7 | |
| SCHEMBL6437992 | 0.77 | KMT2A (0.59) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401841-B1 | SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO 4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN | GRUENENTHAL GMBH (DE) | 2005-08-24 | — | — | EP | disclosed |