Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 1/20 | 0.65 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.65 |
| ▸ | MGLL | Q99685 | 1/20 | 0.63 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.55 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.55 |
| ▸ | BCHE | P06276 | 4/20 | 0.53 |
| ▸ | MAOB | P27338 | 5/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.50 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.50 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6750228 | 0.90 | MGLL (0.74) | CYP4F2CYP4A11MGLLNR4A2FFAR1 | |
| SCHEMBL8577307 | 0.89 | MGLL (0.76) | CYP4F2CYP4A11MGLLNR4A2FFAR1 | |
| SCHEMBL1171455 | 0.88 | MGLL (0.74) | CYP4F2CYP4A11MGLLNR4A2FFAR1 | |
| SCHEMBL1171457 | 0.88 | MGLL (0.74) | CYP4F2CYP4A11MGLLNR4A2FFAR1 | |
| SCHEMBL12493461 | 0.86 | CYP4F2 (0.61) | CYP4F2CYP4A11MGLLNR4A2FFAR1 | |
| SCHEMBL6033828 | 0.84 | FDFT1 (0.54) | FFAR1 | |
| SCHEMBL8855387 | 0.83 | FFAR1 (0.60) | MGLLNR4A2FFAR1BCHE | |
| SCHEMBL1573203 | 0.82 | KDM4E (0.43) | CYP4F2CYP4A11MGLLFFAR1CYP2D6 | |
| SCHEMBL15895227 | 0.80 | TAAR1 (0.57) | — | |
| SCHEMBL3179250 | 0.79 | CYP4F2 (1.00) | CYP4F2CYP4A11MGLLNR4A2FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1090012-A4 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2005-04-06 | — | — | EP | disclosed |
| US-6562823-B1 | Inhibition of farnesyl-protein transferase has been shown to block the growth of Ras-transformed cells in soft agar | MERCK & CO., INC. | 2003-05-13 | — | — | US | disclosed |
| EP-1090012-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000016778-A1 | A METHOD OF TREATING CANCER | MERCK & CO., INC. (US) | 2000-03-30 | — | — | WO | disclosed |
| WO-2000001702-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2000-01-13 | — | — | WO | disclosed |