Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 6/20 | 0.67 |
| ▸ | RARA | P10276 | 5/20 | 0.67 |
| ▸ | RARG | P13631 | 5/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.67 |
| ▸ | PGR | P06401 | 1/20 | 0.67 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.67 |
| ▸ | GOT1 | P17174 | 1/20 | 0.67 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.67 |
| ▸ | BLM | P54132 | 1/20 | 0.67 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.67 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.63 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.63 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.60 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8776315 | 0.92 | RARB (0.64) | RARBRARARARGLMNATDP1 | |
| SCHEMBL566075 | 0.91 | HDAC11 (0.62) | RARBRARARARGLMNATDP1 | |
| SCHEMBL5827886 | 0.89 | RARB (0.70) | RARBRARARARGLMNATDP1 | |
| SCHEMBL13550931 | 0.87 | RARB (0.69) | RARBRARARARGLMNATDP1 | |
| SCHEMBL5827566 | 0.87 | HDAC11 (0.68) | RARBRARARARGLMNATDP1 | |
| SCHEMBL29869357 | 0.87 | RARB (0.69) | RARBRARARARGLMNATDP1 | |
| SCHEMBL10046790 | 0.87 | RARB (0.59) | RARBRARARARGLMNATDP1 | |
| SCHEMBL25206571 | 0.86 | RARB (0.67) | RARBRARARARGLMNATDP1 | |
| SCHEMBL1196452 | 0.86 | RARB (0.67) | RARBRARARARGLMNATDP1 | |
| SCHEMBL14027627 | 0.86 | RARB (0.82) | RARBRARARARGLMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150141696-A1 | PROCESS FOR THE PREPARATION OF ADAPALENE AND RELATED COMPOUNDS | MEDICHEM SA (ES) | 2015-05-21 | — | — | US | claimed |
| US-8871972-B2 | Process for the preparation of adapalene and related compounds | JORDI PUIG SERRANO (ZA) | 2014-10-28 | — | — | US | claimed |
| US-20130030214-A1 | PROCESS FOR THE PREPARATION OF ADAPALENE AND RELATED COMPOUNDS | MEDICHEM, S.A. (ES) | 2013-01-31 | — | — | US | claimed |
| US-8119834-B2 | Process for the preparation of adapalene and related compounds | MEDICHEM, S.A. (ES) | 2012-02-21 | — | — | US | claimed |
| EP-1902010-B1 | PROCESS FOR THE PREPARATION OF ADAPALENE AND RELATED COMPOUNDS | MEDICHEM SA (ES) | 2011-11-30 | — | — | EP | claimed |
| US-20090131713-A1 | Process for the Preparation of Adapalene and Related Compounds | MEDICHEM, S.A. (ES) | 2009-05-21 | — | — | US | claimed |
| EP-1902010-A2 | PROCESS FOR THE PREPARATION OF ADAPALENE AND RELATED COMPOUNDS | Medichem, S.A. (ES) | 2008-03-26 | — | — | EP | claimed |
| WO-2007072217-A2 | PROCESS FOR THE PREPARATION OF ADAPALENE AND RELATED COMPOUNDS | MEDICHEM, S.A. (US) | 2007-06-28 | — | — | WO | claimed |
| US-20150141696-A1 | PROCESS FOR THE PREPARATION OF ADAPALENE AND RELATED COMPOUNDS | MEDICHEM SA (ES) | 2015-05-21 | — | — | US | disclosed |
| US-8871972-B2 | Process for the preparation of adapalene and related compounds | JORDI PUIG SERRANO (ZA) | 2014-10-28 | — | — | US | disclosed |
| US-20130030214-A1 | PROCESS FOR THE PREPARATION OF ADAPALENE AND RELATED COMPOUNDS | MEDICHEM, S.A. (ES) | 2013-01-31 | — | — | US | disclosed |
| US-8119834-B2 | Process for the preparation of adapalene and related compounds | MEDICHEM, S.A. (ES) | 2012-02-21 | — | — | US | disclosed |
| US-8119834-B2 | Process for the preparation of adapalene and related compounds | MEDICHEM, S.A. (ES) | 2012-02-21 | — | — | US | disclosed |
| EP-1902010-B1 | PROCESS FOR THE PREPARATION OF ADAPALENE AND RELATED COMPOUNDS | MEDICHEM SA (ES) | 2011-11-30 | — | — | EP | disclosed |
| US-7498461-B2 | Method for the preparation of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2009-03-03 | — | — | US | disclosed |
| US-7498461-B2 | Method for the preparation of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2009-03-03 | — | — | US | disclosed |
| US-20080091045-A1 | Novel method for the preparation of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2008-04-17 | — | — | US | disclosed |
| US-20080091045-A1 | Novel method for the preparation of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2008-04-17 | — | — | US | disclosed |
| EP-1902010-A2 | PROCESS FOR THE PREPARATION OF ADAPALENE AND RELATED COMPOUNDS | Medichem, S.A. (ES) | 2008-03-26 | — | — | EP | disclosed |
| WO-2007072217-A2 | PROCESS FOR THE PREPARATION OF ADAPALENE AND RELATED COMPOUNDS | MEDICHEM, S.A. (US) | 2007-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080091045-A1 | Novel method for the preparation of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid | CYP2B6, CYP2A6, CYP26B1 | RARB 269/4885RARA 238/4885RARG 1057/4885 |
| US-20090131713-A1 | Process for the Preparation of Adapalene and Related Compounds | DHPS, SQLE, CYP51A1 | RARB 8/4885RARA 9/4885RARG 11/4885 |
| US-20150141696-A1 | PROCESS FOR THE PREPARATION OF ADAPALENE AND RELATED COMPOUNDS | DHPS, SQLE, CYP51A1 | RARB 8/4885RARA 9/4885RARG 11/4885 |
| US-20130030214-A1 | PROCESS FOR THE PREPARATION OF ADAPALENE AND RELATED COMPOUNDS | DHPS, SQLE, CYP51A1 | RARB 8/4885RARA 9/4885RARG 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.