Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 4/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 10/20 | 0.41 |
| ▸ | KDR | P35968 | 7/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CCND3 | P30281 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6410600 | 1.00 | AURKA (0.47) | AURKAAURKBCHEK1KDRFGFR1 | |
| SCHEMBL6414608 | 0.74 | ITK (0.38) | AURKAAURKBCA12CA1CA2 | |
| SCHEMBL6411955 | 0.72 | CKS1B (0.41) | HDAC1CA1CA2CA9ALDH1A1 | |
| SCHEMBL6410524 | 0.71 | ITK (0.52) | CHEK1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL1598189 | 0.70 | AURKA (0.53) | AURKAAURKBCHEK1KDRFGFR1 | |
| Hydrochloric Acid SCHEMBL1598191 | 0.70 | AURKA (0.53) | AURKAAURKBCHEK1KDRFGFR1 | |
| SCHEMBL6410631 | 0.68 | ITK (0.55) | AURKAAURKBCHEK1KDRCDK1 | |
| SCHEMBL6409013 | 0.68 | KDR (0.45) | AURKAAURKBCHEK1KDRFGFR1 | |
| SCHEMBL6409018 | 0.68 | KDR (0.45) | AURKAAURKBCHEK1KDRFGFR1 | |
| SCHEMBL28145939 | 0.65 | CA1 (0.54) | HDAC3HDAC4HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050026984-A1 | Substituted thieno [2,3-c] pyrazoles and their use as medicinal products | AVENTIS PHARMA S.A. (FR) | 2005-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026984-A1 | Substituted thieno [2,3-c] pyrazoles and their use as medicinal products | TPMT, PARK7, PRNP | AURKA 941/4885AURKB 1350/4885CHEK1 474/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.