Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 18/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6410631 | 0.86 | ITK (0.55) | ITKCHEK1 | |
| SCHEMBL6411955 | 0.82 | CKS1B (0.41) | ITKALDH1A1 | |
| SCHEMBL6414608 | 0.81 | ITK (0.38) | ITKALDH1A1 | |
| SCHEMBL4008159 | 0.78 | ITK (0.79) | ITK | |
| SCHEMBL6414471 | 0.78 | PTGES2 (0.41) | ALDH1A1HSD17B10 | |
| SCHEMBL6410583 | 0.76 | CLK2 (0.49) | ITKALDH1A1MAPK1HSD17B10 | |
| SCHEMBL6409034 | 0.75 | ITK (0.52) | ITKCHEK1 | |
| SCHEMBL6410604 | 0.71 | AURKA (0.47) | ALDH1A1CHEK1 | |
| SCHEMBL6410600 | 0.71 | AURKA (0.47) | ALDH1A1CHEK1 | |
| SCHEMBL6415974 | 0.70 | ITK (0.62) | ITKMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050026984-A1 | Substituted thieno [2,3-c] pyrazoles and their use as medicinal products | AVENTIS PHARMA S.A. (FR) | 2005-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026984-A1 | Substituted thieno [2,3-c] pyrazoles and their use as medicinal products | TPMT, PARK7, PRNP | ITK 2307/4885ALDH1A1 696/4885MAPK1 3124/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.