Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 12/20 | 0.33 |
| ▸ | FNTB | P49356 | 12/20 | 0.33 |
| ▸ | PGGT1B | P53609 | 8/20 | 0.33 |
| ▸ | EIF4EBP1 | Q13541 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6416690 | 0.90 | FNTA (0.34) | FNTAFNTBPGGT1B | |
| Trifluoroacetic Acid SCHEMBL6410657 | 0.89 | FNTA (0.34) | FNTAFNTBPGGT1B | |
| Hydrochloric Acid SCHEMBL6469829 | 0.87 | FNTA (0.38) | FNTAFNTBPGGT1B | |
| SCHEMBL6409872 | 0.85 | FNTA (0.33) | FNTAFNTB | |
| SCHEMBL6412093 | 0.85 | FNTA (0.35) | FNTAFNTBPGGT1B | |
| SCHEMBL6416010 | 0.81 | FNTA (0.33) | FNTAFNTBPGGT1B | |
| SCHEMBL6448742 | 0.80 | FNTA (0.37) | FNTAFNTBPGGT1B | |
| SCHEMBL7532834 | 0.80 | FNTA (0.43) | FNTAFNTBPGGT1B | |
| SCHEMBL7161938 | 0.79 | FNTA (0.56) | FNTAFNTBPGGT1B | |
| Hydrochloric Acid SCHEMBL7653568 | 0.79 | FNTA (0.42) | FNTAFNTBPGGT1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1090012-A4 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2005-04-06 | — | — | EP | disclosed |
| US-6562823-B1 | Inhibition of farnesyl-protein transferase has been shown to block the growth of Ras-transformed cells in soft agar | MERCK & CO., INC. | 2003-05-13 | — | — | US | disclosed |
| EP-1090012-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000001702-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2000-01-13 | — | — | WO | disclosed |