Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 2/20 | 0.33 |
| ▸ | FNTB | P49356 | 2/20 | 0.33 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6413043 | 0.89 | FNTA (0.34) | FNTAFNTBTRPV4 | |
| SCHEMBL6410659 | 0.85 | FNTA (0.33) | FNTAFNTB | |
| Hydrochloric Acid SCHEMBL6416653 | 0.83 | FNTA (0.34) | FNTAFNTB | |
| SCHEMBL7160559 | 0.82 | FNTA (0.46) | FNTAFNTB | |
| SCHEMBL6416690 | 0.76 | FNTA (0.34) | FNTAFNTB | |
| Trifluoroacetic Acid SCHEMBL6410657 | 0.75 | FNTA (0.34) | FNTAFNTB | |
| Hydrochloric Acid SCHEMBL6469829 | 0.74 | FNTA (0.38) | FNTAFNTB | |
| Trifluoroacetic Acid SCHEMBL7160557 | 0.73 | FNTA (0.47) | FNTAFNTB | |
| SCHEMBL3684995 | 0.72 | FNTA (0.56) | FNTAFNTB | |
| SCHEMBL3501299 | 0.72 | FNTA (0.56) | FNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1090012-A4 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2005-04-06 | — | — | EP | disclosed |
| US-6562823-B1 | Inhibition of farnesyl-protein transferase has been shown to block the growth of Ras-transformed cells in soft agar | MERCK & CO., INC. | 2003-05-13 | — | — | US | disclosed |
| EP-1090012-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000001702-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2000-01-13 | — | — | WO | disclosed |