Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15309110 | 0.85 | ALDH1A1 (0.51) | ALDH1A1NPSR1MAPTKMT2AMEN1 | |
| SCHEMBL2400918 | 0.84 | ALDH1A1 (0.43) | ALDH1A1NPSR1MAPTKMT2AMEN1 | |
| SCHEMBL6411397 | 0.78 | ALDH1A1 (0.42) | ALDH1A1NPSR1MAPTKMT2AMEN1 | |
| SCHEMBL2400333 | 0.77 | MEN1 (0.41) | ALDH1A1NPSR1MAPTKMT2AMEN1 | |
| SCHEMBL2399960 | 0.77 | ALDH1A1 (0.41) | ALDH1A1NPSR1MAPTKMT2AMEN1 | |
| SCHEMBL6412060 | 0.76 | ALDH1A1 (0.39) | ALDH1A1NPSR1MAPTKMT2AMEN1 | |
| SCHEMBL15309178 | 0.75 | ALDH1A1 (0.42) | ALDH1A1NPSR1MAPTKMT2AMEN1 | |
| SCHEMBL15309153 | 0.73 | HTT (0.52) | ALDH1A1NPSR1MAPTKMT2AMEN1 | |
| SCHEMBL6412218 | 0.71 | ALDH1A1 (0.40) | ALDH1A1NPSR1MAPTKMT2AMEN1 | |
| SCHEMBL2401311 | 0.68 | GPR119 (0.52) | ALDH1A1NPSR1MAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401841-B1 | SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO 4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN | GRUENENTHAL GMBH (DE) | 2005-08-24 | — | — | EP | claimed |