SCHEMBL6410941

SCHEMBL6410941

CCSCCNC(=O)OC1=NOC2(CCN(C(=O)c3cc(C(C)(C)C)nn3C)CC2)C1

nearest known ligand 0.40

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
NAMPT P43490 1/20 0.40
EPHX2 P34913 1/20 0.35
CTSL P07711 3/20 0.34
CTSS P25774 1/20 0.34
CTSK P43235 1/20 0.34
GALR3 O60755 3/20 0.33
LMNA P02545 2/20 0.33
RAB9A P51151 1/20 0.33
TSHR P16473 1/20 0.33
HTT P42858 1/20 0.33
KDM4E B2RXH2 1/20 0.33
GRN P28799 1/20 0.33
SORT1 Q99523 1/20 0.33
NAA50 Q9GZZ1 3/20 0.33
CTSB P07858 1/20 0.33
ALDH1A1 P00352 1/20 0.32
NR2F2 P24468 1/20 0.31
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2581246 0.86 NAMPT (0.43) NAMPTEPHX2CTSLCTSSCTSK
SCHEMBL6418537 0.83 KDM4E (0.44) NAMPTEPHX2CTSLCTSSCTSK
SCHEMBL6413167 0.78 FPR3 (0.37) LMNAALDH1A1KMT2A
SCHEMBL6413925 0.75 GRN (0.50) NAMPTEPHX2CTSLCTSSCTSK
SCHEMBL6411323 0.72 GAA (0.35) ALDH1A1MEN1KMT2A
SCHEMBL6410679 0.69 KMT2A (0.53) LMNATSHRKDM4EALDH1A1MEN1
SCHEMBL6411397 0.66 ALDH1A1 (0.42) LMNATSHRHTTALDH1A1MEN1
SCHEMBL4817606 0.65 KDM4E (0.54) NAMPTEPHX2CTSLCTSSCTSK
SCHEMBL4817595 0.65 KDM4E (0.54) NAMPTEPHX2CTSLCTSSCTSK
SCHEMBL6409808 0.64 SMN1; SMN2 (0.48) KDM4EMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1401841-B1 SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO 4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN GRUENENTHAL GMBH (DE) 2005-08-24 EP claimed
EP-1401841-A1 SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO 4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN Grünenthal GmbH (DE) 2004-03-31 EP claimed
WO-2003000699-A1 SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO[4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN Grünenthal GmbH (DE) 2003-01-03 WO claimed
EP-1401841-B1 SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO 4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN GRUENENTHAL GMBH (DE) 2005-08-24 EP disclosed
EP-1401841-A1 SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO 4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN Grünenthal GmbH (DE) 2004-03-31 EP disclosed
WO-2003000699-A1 SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO[4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN Grünenthal GmbH (DE) 2003-01-03 WO disclosed