Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | GSK3B | P49841 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.50 |
| ▸ | FEN1 | P39748 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | CES2 | O00748 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 1/20 | 0.48 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28750358 | 0.89 | MMP1 (0.55) | POLBGSK3BL3MBTL1CYP2C9CYP2C19 | |
| SCHEMBL11839825 | 0.86 | POLB (0.58) | POLBGSK3BL3MBTL1CYP2C9CYP2C19 | |
| SCHEMBL16313486 | 0.84 | POLB (0.57) | POLBGSK3BL3MBTL1CYP2C9CYP2C19 | |
| SCHEMBL3031841 | 0.84 | POLB (0.57) | POLBGSK3BL3MBTL1CYP2C9CYP2C19 | |
| SCHEMBL17148448 | 0.83 | KMT2A (0.52) | POLBL3MBTL1RAB9AKMT2AMAPT | |
| SCHEMBL8306301 | 0.82 | POLB (0.64) | POLBGSK3BL3MBTL1CYP2C9CYP2C19 | |
| SCHEMBL11187061 | 0.81 | POLB (0.54) | POLBGSK3BL3MBTL1CYP2C9CYP2C19 | |
| SCHEMBL5310609 | 0.81 | POLB (0.54) | POLBGSK3BL3MBTL1CYP2C9CYP2C19 | |
| SCHEMBL6781250 | 0.81 | HSD17B3 (0.55) | POLBL3MBTL1NPC1RAB9AALDH1A1 | |
| SCHEMBL507140 | 0.81 | GSK3B (0.57) | POLBGSK3BL3MBTL1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114315667-B | Preparation method and application of 2-methyl-2-chloro-1- [4- (methylthio) phenyl ] -1-propanone | 湖南久日新材料有限公司 | 2024-12-31 | — | — | CN | disclosed |
| WO-2023196556-A1 | CANNABINOID RECEPTOR 1 ANTAGONISTS/INVERSE AGONISTS AND USES THEREOF | CORBUS PHARMACEUTICALS, INC. (US) | 2023-10-12 | — | — | WO | disclosed |
| WO-2023086799-A1 | HETEROCYCLIC COMPOUNDS AS TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2 AGONISTS | VIGIL NEUROSCIENCE, INC. (US) | 2023-05-19 | — | — | WO | disclosed |
| WO-2023086800-A1 | HETEROCYCLIC COMPOUNDS AS TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2 AGONISTS AND METHODS OF USE | VIGIL NEUROSCIENCE, INC. (US) | 2023-05-19 | — | — | WO | disclosed |
| CN-113045532-A | Intermediate for preparing S-flurbiprofen and preparation method and application thereof | 上海医药工业研究院 | 2021-06-29 | — | — | CN | disclosed |
| EP-3702355-A1 | SUBSTITUTED PYRAZOLE COMPOUNDS CONTAINING PYRIMIDINE, THE PREPARATION AND APPLICATION THEREOF | Shenyang Sinochem Agrochemicals R&D Co., Ltd. (CN) | 2020-09-02 | — | — | EP | disclosed |
| US-20180071257-A1 | DIAZOLE AMIDES | CHEMOCENTRYX, INC. | 2018-03-15 | — | — | US | disclosed |
| US-9770026-B2 | Substituted pyrimidine compound and uses thereof | SHENYANG SINOCHEM AGROCHEMICALS R&D CO., LTD. (CN) | 2017-09-26 | — | — | US | disclosed |
| US-9750722-B2 | Diazole amides | CHEMOCENTRYX, INC. (US) | 2017-09-05 | — | — | US | disclosed |
| US-20160193185-A1 | DIAZOLE AMIDES | CHEMOCENTRYX, INC. | 2016-07-07 | — | — | US | disclosed |
| EP-0210589-B1 | PROCESS FOR PREPARING OPTICALLY ACTIVE ALPHA-HALOGEN KETALS | ZAMBON S.p.A. (IT) | 1990-09-26 | — | — | EP | disclosed |
| US-4888433-A | CHIRAL HALOGENATED KETALS WHICH UNDERGO STEREOSELECTIVE REARRANGEMENT | ZAMBON, S.P.A. (IT) | 1989-12-19 | — | — | US | disclosed |
| US-4861903-A | Intermediates for preparing optically active carboxylic acids | ZAMBON SPA (IT) | 1989-08-29 | — | — | US | disclosed |
| US-4810819-A | STEREOSELECTIVE HALOGENATION AND REARRANGEMENT | ZAMBON SPA (IT) | 1989-03-07 | — | — | US | disclosed |
| US-4759789-A | Treating locus of plant before or during application of herbicide with oxime ether compound | CIBA-GEIGY CORPORATION (US) | 1988-07-26 | — | — | US | disclosed |
| EP-0158913-B1 | PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE ALPHA-ARYLALKANOIC ACIDS AND INTERMEDIATES THEREOF | ZAMBON S.p.A. (IT) | 1988-07-20 | — | — | EP | disclosed |
| US-4697036-A | HALOGENATION, REARRANGEMENT | ZAMBON S.P.A. (IT) | 1987-09-29 | — | — | US | disclosed |
| EP-0210589-A2 | Process for preparing optically active alpha-halogen ketals | ZAMBON S.p.A. (IT) | 1987-02-04 | — | — | EP | disclosed |
| US-4566901-A | PLANT SAFENING AGENTS | CIBA-GEIGY CORPORATION (US) | 1986-01-28 | — | — | US | disclosed |
| EP-0158913-A2 | Process for the preparation of optically active alpha-arylalkanoic acids and intermediates thereof | ZAMBON S.p.A. (IT) | 1985-10-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180071257-A1 | DIAZOLE AMIDES | CCR1, CCRL2, CCR4 | POLB 3771/4885GSK3B 3023/4885L3MBTL1 614/4885 |
| US-20160193185-A1 | DIAZOLE AMIDES | CCR1, CCRL2, CCR4 | POLB 3771/4885GSK3B 3023/4885L3MBTL1 614/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.