Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | NAMPT | P43490 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11380712 | 0.81 | KDM4E (0.70) | THRBKMT2AKDM4EALOX15TSHR | |
| SCHEMBL11347453 | 0.75 | HDAC3 (0.65) | KMT2AKDM4EALOX15TSHRSIRT1 | |
| SCHEMBL6417347 | 0.73 | POLB (0.57) | GAAKMT2AMAPTALDH1A1NPSR1 | |
| SCHEMBL11374450 | 0.73 | CHRM2 (0.52) | TP53KMT2AKDM4EALOX15TSHR | |
| SCHEMBL11386196 | 0.73 | KDM4E (0.51) | GAAKMT2AKDM4EALOX15TSHR | |
| SCHEMBL11378809 | 0.73 | KDM4E (0.51) | GAAKMT2AKDM4EALOX15TSHR | |
| SCHEMBL30089331 | 0.73 | GAA (0.51) | TP53GAAATMTHRBKMT2A | |
| SCHEMBL6038207 | 0.73 | LMNA (0.47) | GAAATMTHRBALOX15ALDH1A1 | |
| SCHEMBL9033333 | 0.73 | KMT2A (0.66) | ATMKMT2AKDM4ETSHRMAPT | |
| SCHEMBL15233568 | 0.72 | KDM4E (0.75) | THRBKMT2AKDM4EALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8771944-B2 | Use of micro-RNA as a biomarker of immunomodulatory drug activity | CELGENE CORPORATION (US) | 2014-07-08 | — | — | US | disclosed |
| EP-1581205-A1 | METHODS OF USING AND COMPOSITIONS COMPRISING (+)-3-(3,4-DIMETHOXY-PHENYL)-3-(1-OXO-1,3-DIHYDRO-ISOINDOL-2-YL)-PROPIONAMIDE | CELGENE CORPORATION (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004045597-A1 | METHODS OF USING AND COMPOSITIONS COMPRISING (+)-3-(3,4-DIMETHOXY-PHENYL)-3-(1-OXO-1,3-DIHYDRO-ISOINDOL-2-YL)-PROPIONAMIDE | CELGENE CORPORATION (US) | 2004-06-03 | — | — | WO | disclosed |