Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6410922 | 0.88 | POLB (0.38) | LMNAMAPTSMN1; SMN2HTTALDH1A1 | |
| SCHEMBL2404605 | 0.87 | L3MBTL1 (0.47) | L3MBTL1LMNAEPHX2MAPTSMN1; SMN2 | |
| SCHEMBL6411644 | 0.85 | L3MBTL1 (0.53) | L3MBTL1LMNAEPHX2MAPTSMN1; SMN2 | |
| SCHEMBL6411481 | 0.82 | POLB (0.44) | HTTALDH1A1GAAPOLBCYP3A4 | |
| SCHEMBL6409957 | 0.80 | KMT2A (0.45) | L3MBTL1MAPTSMN1; SMN2ALDH1A1GAA | |
| SCHEMBL6414941 | 0.78 | TP53 (0.38) | LMNAMAPTSMN1; SMN2HTTALDH1A1 | |
| SCHEMBL6411638 | 0.78 | L3MBTL1 (0.57) | L3MBTL1LMNAEPHX2MAPTSMN1; SMN2 | |
| SCHEMBL2400766 | 0.76 | L3MBTL1 (0.45) | L3MBTL1LMNAEPHX2MAPTSMN1; SMN2 | |
| SCHEMBL2402512 | 0.75 | EPHX2 (0.49) | L3MBTL1LMNAEPHX2MAPTSMN1; SMN2 | |
| SCHEMBL2404658 | 0.74 | POLB (0.41) | LMNAMAPTSMN1; SMN2HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401841-B1 | SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO 4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN | GRUENENTHAL GMBH (DE) | 2005-08-24 | — | — | EP | claimed |
| EP-1401841-B1 | SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO 4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN | GRUENENTHAL GMBH (DE) | 2005-08-24 | — | — | EP | disclosed |